Macilwain C. Systems biology: evolving into the mainstream. Cell. 2011 Mar 18;144(6):839-41. PubMed PMID: 21414474.
Arkin AP, Schaffer DV. Network news: innovations in 21st century systems biology. Cell. 2011 Mar 18;144(6):844-9. PubMed PMID: 21414475.
Nurse P, Hayles J. The cell in an era of systems biology. Cell. 2011 Mar 18;144(6):850-4. PubMed PMID: 21414476.
Smolke CD, Silver PA. Informing biological design by integration of systems and synthetic biology. Cell. 2011 Mar 18;144(6):855-9. PubMed PMID: 21414477.
Ideker T, Dutkowski J, Hood L. Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power. Cell. 2011 Mar 18;144(6):860-3. PubMed PMID: 21414478.
Pe’er D, Hacohen N. Principles and strategies for developing network models in cancer. Cell. 2011 Mar 18;144(6):864-73. PubMed PMID: 21414479.
Ferrell JE Jr, Tsai TY, Yang Q. Modeling the cell cycle: why do certain circuits oscillate? Cell. 2011 Mar 18;144(6):874-85. PubMed PMID: 21414480.
Yosef N, Regev A. Impulse control: temporal dynamics in gene transcription. Cell. 2011 Mar 18;144(6):886-96. PubMed PMID: 21414481.
Grecco HE, Schmick M, Bastiaens PI. Signaling from the living plasma membrane. Cell. 2011 Mar 18;144(6):897-909. PubMed PMID: 21414482.
Balázsi G, van Oudenaarden A, Collins JJ. Cellular decision making and biological noise: from microbes to mammals. Cell. 2011 Mar 18;144(6):910-25. PubMed PMID: 21414483.
Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18;144(6):926-39. PubMed PMID: 21414484.
Young RA. Control of the embryonic stem cell state. Cell. 2011 Mar 18;144(6):940-54. PubMed PMID: 21414485.
Lander AD. Pattern, growth, and control. Cell. 2011 Mar 18;144(6):955-69. PubMed PMID: 21414486.
Peter IS, Davidson EH. Evolution of gene regulatory networks controlling body plan development. Cell. 2011 Mar 18;144(6):970-85. PubMed PMID: 21414487.
Vidal M, Cusick ME, Barabási AL. Interactome networks and human disease. Cell. 2011 Mar 18;144(6):986-98. PubMed PMID: 21414488.
González F, Boué S, Belmonte JC. Methods for making induced pluripotent stem cells: reprogramming à la carte. Nat Rev Genet. 2011 Apr;12(4):231-42. Epub 2011 Feb 22. PubMed PMID: 21339765.
Cohen DE, Melton D. Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet. 2011 Apr;12(4):243-52. Epub 2011 Mar 9. PubMed PMID: 21386864.
Plath K, Lowry WE. Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet. 2011 Apr;12(4):253-65. PubMed PMID: 21415849.
Zhu H, Lensch MW, Cahan P, Daley GQ. Investigating monogenic and complex diseases with pluripotent stem cells. Nat Rev Genet. 2011 Apr;12(4):266-75. Epub 2011 Mar 9. PubMed PMID: 21386866.
Montgomery SB, Dermitzakis ET. From expression QTLs to personalized transcriptomics. Nat Rev Genet. 2011 Apr;12(4):277-82. Epub 2011 Mar 9. PubMed PMID: 21386863.
Ong CT, Corces VG. Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet. 2011 Apr;12(4):283-93. Epub 2011 Mar 1. PubMed PMID: 21358745.
Ledford H. Hidden toll of embryo ethics war. Nature. 2011 Mar 17;471(7338):279. PubMed PMID: 21412306.
Abbott A. Europe rules against stem-cell patents. Nature. 2011 Mar 17;471(7338):280. PubMed PMID: 21412307.
Neuroscience
Bock DD, Lee WC, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC. Network anatomy and in vivo physiology of visual cortical neurons. Nature. 2011 Mar 10;471(7337):177-82. PubMed PMID: 21390124.
Briggman KL, Helmstaedter M, Denk W. Wiring specificity in the direction-selectivity circuit of the retina. Nature. 2011 Mar 10;471(7337):183-8. PubMed PMID: 21390125.
Commentary: Seung HS. Neuroscience: Towards functional connectomics. Nature. 2011 Mar 10;471(7337):170-2. PubMed PMID: 2139011
Retinal pigment epithelium
Iacovelli J, Zhao C, Wolkow N, Veldman P, Gollomp K, Ojha P, Lukinova N, King A, Feiner L, Esumi N, Zack DJ, Pierce EA, Vollrath D, Dunaief JL. Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression. Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1378-83. Print 2011 Mar. PubMed PMID: 21212186.
Regeneration
Kikuchi K, Holdway JE, Major RJ, Blum N, Dahn RD, Begemann G, Poss KD. Retinoic Acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev Cell. 2011 Mar 15;20(3):397-404. PubMed PMID: 21397850.
Retina
Mollema NJ, Yuan Y, Jelcick AS, Sachs AJ, von Alpen D, Schorderet D, Escher P, Haider NB. Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina. PLoS One. 2011 Mar 8;6(3):e17494. PubMed PMID: 21408158.
Minke B, Peters M. Cell biology. Rhodopsin as thermosensor? Science. 2011 Mar 11;331(6022):1272-3. PubMed PMID: 21393531.
Eye disease
Volkmann BA, Zinkevich NS, Mustonen A, Schilter KF, Bosenko DV, Reis LM, Broeckel U, Link BA, Semina E. Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2. Invest Ophthalmol Vis Sci. 2010 Sep 29. [Epub ahead of print] PubMed PMID: 20881290.
Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17;471(7338):325-30. Epub 2011 Feb 6. PubMed PMID: 21297615.
Commentary: Meister G. Vision: Dicer leaps into view. Nature. 2011 Mar 17;471(7338):308-9. PubMed PMID: 21412326.
A new way of causing geographical atrophy by an unknown role of DICER.
Disease
Kawahara G, Karpf JA, Myers JA, Alexander MS, Guyon JR, Kunkel LM. Drug screening in a zebrafish model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2011 Mar 14. [Epub ahead of print] PubMed PMID: 21402949.
Behavior
Cachat J, Stewart A, Utterback E, Hart P, Gaikwad S, Wong K, Kyzar E, Wu N, Kalueff AV. Three-dimensional neurophenotyping of adult zebrafish behavior. PLoS One. 2011 Mar 7;6(3):e17597. PubMed PMID: 21408171.
Development
England SJ, Blanchard GB, Mahadevan L, Adams RJ. A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia. Development. 2006 Dec;133(23):4613-7. Epub 2006 Nov 1. PubMed PMID: 17079266.
Publicover S, Barratt C. Reproductive biology: Progesterone’s gateway into sperm. Nature. 2011 Mar 17;471(7338):313-4. PubMed PMID: 21412330.
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Mallarino R, Grant PR, Grant BR, Herrel A, Kuo WP, Abzhanov A. Two developmental modules establish 3D beak-shape variation in Darwin’s finches. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4057-62. Epub 2011 Feb 22. PubMed PMID: 21368127.
Signal transduction
Pierfelice T, Alberi L, Gaiano N. Notch in the vertebrate nervous system: an old dog with new tricks. Neuron. 2011 Mar 10;69(5):840-55. PubMed PMID: 21382546.
Systems biology
Heo M, Maslov S, Shakhnovich E. Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4258-63. Epub 2011 Feb 22. PubMed PMID: 21368118.
Stem cells
Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, Macdermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol. 2011 Mar;29(3):279-86. Epub 2011 Feb 3. PubMed PMID: 21293464.
Commentary: Kim H, Studer L. IPSCs put to the test. Nat Biotechnol. 2011 Mar;29(3):233-5. PubMed PMID: 21390027.
Schwartz MA. The importance of stupidity in scientific research. J Cell Sci. 2008 Jun 1;121(Pt 11):1771. PubMed PMID: 18492790.
What is the difference between class room learning and research? Is being good in class room good enough to make one a research scientist?
Systems biology
Burrill DR, Silver PA. Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev. 2011 Mar 1;25(5):434-9. PubMed PMID: 21363961.
Genomics
Pique-Regi R, Degner JF, Pai AA, Gaffney DJ, Gilad Y, Pritchard JK. Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data. Genome Res. 2011 Mar;21(3):447-55. Epub 2010 Nov 24. PubMed PMID: 21106904.
Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W; the Inflammation and Host Response to Injury Large-Scale Collaborative Research Program. Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3707-3712. Epub 2011 Feb 11. PubMed PMID: 21317363.
A comparative study of RNA-seq and microarrays for disease research. The authors showed that the performance of microarrays, can be more reliable than RNA-seq. That includes a higher sensitivity at the exon level for the low abundance transcripts
Maxmen A. Exome sequencing deciphers rare diseases. Cell. 2011 Mar 4;144(5):635-7. PubMed PMID: 21376225.
Whole genome sequencing helps to find the disease genes that haven’t been able to mapped.
Bioinformatics
Swedlow JR. Finding an image in a haystack: the case for public image repositories. Nat Cell Biol. 2011 Mar;13(3):183. PubMed PMID: 21364564.
Behaviour
Mathur P, Lau B, Guo S. Conditioned place preference behavior in zebrafish. Nat Protoc. 2011 Feb;6(3):338-45. Epub 2011 Feb 24. PubMed PMID: 21372814.
Retina
Lamba DA, Reh TA. Microarray Characterization of Human Embryonic Stem Cell-Derived Retinal Cultures. Invest Ophthalmol Vis Sci. 2011 Feb 23. [Epub ahead of print] PubMed PMID: 21345990.
Roberts MR, Srinivas M, Forrest D, Morreale de Escobar G, Reh TA. Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6218-23. Epub 2006 Apr 10. PubMed PMID: 16606843; PubMed Central PMCID: PMC1458858.
Neuroscience
Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell. 2011 Mar 4;144(5):810-23. PubMed PMID: 21376239.
Commentary Bezzi P, Volterra A. Astrocytes: powering memory. Cell. 2011 Mar 4;144(5):644-5. PubMed PMID: 21376229.
Anderson JR, Gallup GG. Which primates recognize themselves in mirrors? PLoSBiol. 2011 Mar;9(3):e1001024. Epub 2011 Mar 1. PubMed PMID: 21390247.
Cancer
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. PubMed PMID: 21376230.
Epidemiology
The longest longitudinal study of the same group of people starting from birth to 65 years old! Many interesting observations.
The generation game. Nature. 2011 Mar 3;471(7336):5. PubMed PMID: 21368778.
Pearson H. Epidemiology: Study of a lifetime. Nature. 2011 Mar 3;471(7336):20-4. PubMed PMID: 21368799.
Development
Wartlick O, Mumcu P, Kicheva A, Bittig T, Seum C, Jülicher F, González-Gaitán M. Dynamics of Dpp signaling and proliferation control. Science. 2011 Mar 4;331(6021):1154-9. PubMed PMID: 21385708.
Commentary: Le Goff L, Lecuit T. Developmental biology. Gradient scaling and growth. Science. 2011 Mar 4;331(6021):1141-2. PubMed PMID: 21385701.
Stem cells
A series of papers reveal the differences of iPS cells, suggesting more research has to be done before using these cells to treat human disease.
Commentary: Pera MF. Stem cells: The dark side of induced pluripotency. Nature. 2011 Mar 3;471(7336):46-7. PubMed PMID: 21368819.
Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O’Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011 Mar 3;471(7336):68-73. Epub 2011 Feb 2. PubMed PMID: 21289626.
Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar
3;471(7336):63-7. PubMed PMID: 21368825.
Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones DP, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T. Copy number variation and selection during reprogramming to pluripotency. Nature. 2011 Mar 3;471(7336):58-62. PubMed PMID: 21368824.
Structural biology
Spudich JA. Biochemistry. Molecular motors, beauty in complexity. Science. 2011 Mar 4;331(6021):1143-4. PubMed PMID: 21385703.
Eye
Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA. Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma. PLoS Genet. 2011 Feb;7(2):e1001310. Epub 2011 Feb 17. PubMed PMID: 21379331; PubMed Central PMCID: PMC3040661.
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Dubey GP, Ben-Yehuda S. Intercellular nanotubes mediate bacterial communication. Cell. 2011 Feb 18;144(4):590-600. PubMed PMID: 21335240.
A new way of bacterial communication is discovered.
Genetics/ Genomics
Takashima Y, Ohtsuka T, González A, Miyachi H, Kageyama R. Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A. 2011 Feb 7. [Epub ahead of print] PubMed PMID: 21300886.
Nikolova EN, Kim E, Wise AA, O’Brien PJ, Andricioaei I, Al-Hashimi HM. Transient Hoogsteen base pairs in canonical duplex DNA. Nature. 2011 Feb 24;470(7335):498-502. Epub 2011 Jan 26. PubMed PMID: 21270796.
Commentary: Honig B, Rohs R. Biophysics: Flipping Watson and Crick. Nature. 2011 Feb 24;470(7335):472-3. PubMed PMID: 21350476.
A possible 3D configuration of DNA is in equilibrium with the regular DNA, thus expanding the variety of the possible DNA recognition.
Kedes L, Liu E, Jongeneel CV, Sutton G. Judging the Archon Genomics X PRIZE for whole human genome sequencing. Nat Genet. 2011 Mar;43(3):175. PubMed PMID: 21350493.
Towards a medical grade human genome sequence. Nat Genet. 2011 Mar;43(3):173. PubMed PMID: 21350492.
Development
Manceau M, Domingues VS, Mallarino R, Hoekstra HE. The developmental role of Agouti in color pattern evolution. Science. 2011 Feb 25;331(6020):1062-5. PubMedPMID: 21350176.
Retinal development
Kerschensteiner D. Circuit assembly: the repulsive side of lamination. Curr Biol. 2011 Feb 22;21(4):R163-6. PubMed PMID: 21334299.
Whitney IE, Raven MA, Lu L, Williams RW, Reese BE. A QTL on Chromosome 10 Modulates Cone Photoreceptor Number in the Mouse Retina. Invest Ophthalmol Vis Sci. 2011 Feb 17. [Epub ahead of print] PubMed PMID: 21330668.
Neurodevelopment
A series of brainbow applications and modifications!
Card JP, Kobiler O, McCambridge J, Ebdlahad S, Shan Z, Raizada MK, Sved AF, Enquist LW. Microdissection of neural networks by conditional reporter expression from a Brainbow herpesvirus. Proc Natl Acad Sci U S A. 2011 Feb 3. [Epub ahead of print] PubMed PMID: 21292985.
Hampel S, Chung P, McKellar CE, Hall D, Looger LL, Simpson JH. Drosophila Brainbow: a recombinase-based fluorescence labeling technique to subdivide neural expression patterns. Nat Methods. 2011 Mar;8(3):253-9. Epub 2011 Feb 6. PubMed PMID: 21297621.
Hadjieconomou D, Rotkopf S, Alexandre C, Bell DM, Dickson BJ, Salecker I. Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster. Nat Methods. 2011 Mar;8(3):260-6. Epub 2011 Feb 6. PubMed PMID: 21297619.
Regeneration
Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science. 2011 Feb 25;331(6020):1078-80. PubMed PMID: 21350179.
Cdk5
Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga SI. Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. J Neurochem. 2011 Feb 21. doi: 10.1111/j.1471-4159.2011.07222.x. [Epub ahead of print] PubMed PMID: 21338355.
Ethical, Social and Legal Issues
Ceci SJ, Williams WM. Understanding current causes of women’s underrepresentation in science. Proc Natl Acad Sci U S A. 2011 Feb 7. [Epub ahead of print] PubMed PMID: 21300892.
Muggah R. Measuring the true costs of war: consensus and controversy. PLoS Med. 2011 Feb 15;8(2):e1000417. PubMed PMID: 21358809; PubMed Central PMCID: PMC3039686.
Hicks MH, Dardagan H, Guerrero Serdán G, Bagnall PM, Sloboda JA, Spagat M. Violent deaths of iraqi civilians, 2003-2008: analysis by perpetrator, weapon, time, and location. PLoS Med. 2011 Feb 15;8(2):e1000415. PubMed PMID: 21358813; PubMed Central PMCID: PMC3039690.
Research Funding
Cho A. U.S. science budget. House cuts to DOE national labs would also hamstring industry. Science. 2011 Feb 25;331(6020):997-8. PubMed PMID: 21350135.
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Xu Z, Wei W, Gagneur J, Clauder-Münster S, Smolik M, Huber W, Steinmetz LM. Antisense expression increases gene expression variability and locus interdependency. Mol Syst Biol. 2011 Feb 15;7:468. PubMed PMID: 21326235.
Tewhey R, Bansal V, Torkamani A, Topol EJ, Schork NJ. The importance of phase information for human genomics. Nat Rev Genet. 2011 Mar;12(3):215-223. Epub 2011 Feb 8. PubMed PMID: 21301473.
Development
Wu D, Freund JB, Fraser SE, Vermot J. Mechanistic Basis of Otolith Formation during Teleost Inner Ear Development. Dev Cell. 2011 Feb 15;20(2):271-8. PubMed PMID: 21316594.
Davidson EH. Evolutionary bioscience as regulatory systems biology. Dev Biol. 2011 Feb 11. [Epub ahead of print] PubMed PMID: 21320483.
Retina
Jusuf PR, Almeida AD, Randlett O, Joubin K, Poggi L, Harris WA. Origin and determination of inhibitory cell lineages in the vertebrate retina. J Neurosci. 2011 Feb 16;31(7):2549-62. PubMed PMID: 21325522.
Gene regulatory network
Macneil L, Walhout AJ. Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression. Genome Res. 2011 Feb 4. [Epub ahead of print] PubMed PMID: 21324878.
Taati S, Formenti E, Comet JP, Bernot G. On the impact of the distance between two genes on their interaction curve. J Math Biol. 2011 Feb 15. [Epub ahead of print] PubMed PMID: 21327639.
Systems biology
Plotkin JB. Cell biology. The lives of proteins. Science. 2011 Feb 11;331(6018):683-4. PubMed PMID: 21310990.
Eden E, Geva-Zatorsky N, Issaeva I, Cohen A, Dekel E, Danon T, Cohen L, Mayo A, Alon U. Proteome half-life dynamics in living human cells. Science. 2011 Feb 11;331(6018):764-8. Epub 2011 Jan 13. PubMed PMID: 21233346.
Minc N, Burgess D, Chang F. Influence of cell geometry on division-plane positioning. Cell. 2011 Feb 4;144(3):414-26. PubMed PMID: 21295701.
Gibson WT, Veldhuis JH, Rubinstein B, Cartwright HN, Perrimon N, Brodland GW, Nagpal R, Gibson MC. Control of the mitotic cleavage plane by local epithelial topology. Cell. 2011 Feb 4;144(3):427-38. PubMed PMID: 21295702.
Stem cells
Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A. Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines. Cell. 2011 Feb 4;144(3):439-52. PubMed PMID: 21295703.
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It has always been my role to tell you the reality and teach you how to fish, and not giving you a fish, nor the bogus “American Dream” or things-will-somehow-get-better hope. I have been saying for a while that the economy is going to be much worse and now the really hard time is going to come.
The House approved one of the biggest cuts in US history. When they were discussing this, there were many scientists trying to oppose to the plan, including FASEB. Why? Look at the numbers, among the comprehensive cuts in all governmental agencies, here are a few that we are very familiar with:
NSF -$139M
CDC -$755M
NIH -$1B
One billion cut at NIH means that the funding rate will become even lower and many programs will not be sustained. As they also put it
Make no mistake, these cuts are not low-hanging fruit. These cuts are real and will impact every District across the country”.
Put it simply, it is a survival game. There is nowhere to hide in society now given the budget cut, poor fundamentals of the US economy and societal structure. Those who want to get a chance (note: it is “getting a chance”) to survive need to show their very best in this modernized jungle. You need to fight very hard for your chance and survival. If you possess the “American-Dream” mentality that “I have done everything and I have tried, hence I deserve an “A” or “X”, despite things didn’t work out”, you will have trouble in this game.
Lander ES. Initial impact of the sequencing of the human genome. Nature. 2011 Feb 10;470(7333):187-97. PubMed PMID: 21307931.
Eric is one of the leaders in the human genome sequencing project. In this review that celebrates the publication of human genome sequence 10 years ago, he highlights major discoveries at all levels, from how we understand gene, genome structure and regulation, to how we understand
disease, map disease genes, find better treatments and to the evolution of human kind. This is an article that you can’t miss if you are serious about studying biology.
Mardis ER. A decade’s perspective on DNA sequencing technology. Nature. 2011 Feb 10;470(7333):198-203. PubMed PMID: 21307932.
Green ED, Guyer MS; National Human Genome Research Institute. Charting a course for genomic medicine from base pairs to bedside. Nature. 2011 Feb 10;470(7333):204-13. PubMed PMID: 21307933.
Evolution and Human Behavior
Kermyt G. Anderson. Does paying child support reduce men’s subsequent marriage and fertility? Evol Hum Behav. 2011; 32: 90-96
Drew H. Bailey, Kristina M. Durante, David C. Geary. Men’s perception of women’s attractiveness is calibrated to relative mate value and dominance of the women’s partner. Evol Hum Behav. 2011; 32: 138-146
Jeffrey K. Snyder, Daniel M.T. Fessler, Leonid Tiokhin, David A. Frederick, Sok Woo Lee, Carlos David Navarrete. Trade-offs in a dangerous world: women’s fear of crime predicts preferences for aggressive and formidable mates. Evol Hum Behav. 2011; 32: 127-137
Dina Dosmukhambetova, Antony Manstead. Strategic reactions to unfaithfulness: female self-presentation in the context of mate attraction is linked to uncertainty of paternity. Evol Hum Behav. 2011; 106-117.
Stem cells
Wadman M. Stem cells: The crusader. Nature. 2011 Feb 10;470(7333):156-9. PubMed PMID: 21307911.
Retina
Matsuoka RL, Nguyen-Ba-Charvet KT, Parray A, Badea TC, Chédotal A, Kolodkin AL. Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina. Nature. 2011 Jan 26;470(7333):259-263. [Epub ahead of print] PubMed PMID: 21270798.
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Kim J, Winfree E. Synthetic in vitro transcriptional oscillators. Mol Syst Biol. 2011 Feb 1;7:465. PubMed PMID: 21283141.
Montagne K, Plasson R, Sakai Y, Fujii T, Rondelez Y. Programming an in vitro DNA oscillator using a molecular networking strategy. Mol Syst Biol. 2011 Feb 1;7:466. PubMed PMID: 21283142.
Bachman JA, Sorger P. New approaches to modeling complex biochemistry. Nat Methods. 2011 Feb;8(2):130-1. PubMed PMID: 21278724.
Sneddon MW, Faeder JR, Emonet T. Efficient modeling, simulation and coarse-graining of biological complexity with NFsim. Nat Methods. 2011 Feb;8(2):177-83. Epub 2010 Dec 26. PubMed PMID: 21186362.
Genetics
Clarke GM, Anderson CA, Pettersson FH, Cardon LR, Morris AP, Zondervan KT. Basic statistical analysis in genetic case-control studies. Nat Protoc. 2011 Feb;6(2):121-33. Epub 2011 Feb 3. PubMed PMID: 21293453.
Zebrafish
Blackburn JS, Liu S, Raimondi AR, Ignatius MS, Salthouse CD, Langenau DM. High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope. Nat Protoc. 2011 Feb;6(2):229-41. Epub 2011 Feb 3. PubMed PMID: 21293462.
Development & Regeneration
Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011 Feb 3;470(7332):95-100. Epub 2011 Jan 26. PubMed PMID: 21270795.
Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011 Feb 3;470(7332):105-9. Epub 2010 Dec 12. PubMed PMID: 21151107; PubMed Central PMCID: PMC3033971.
Imaging
Bewersdorf J, Farese RV Jr, Walther TC. A new way to look at fat. Nat Methods. 2011 Feb;8(2):132-3. PubMed PMID: 21278725.
Lionnet T, Czaplinski K, Darzacq X, Shav-Tal Y, Wells AL, Chao JA, Park HY, de Turris V, Lopez-Jones M, Singer RH. A transgenic mouse for in vivo detection of endogenous labeled mRNA. Nat Methods. 2011 Feb;8(2):165-70. Epub 2011 Jan 16. PubMed PMID: 21240280.
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