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How to fund research so that it generates insanely great ideas, not pretty good ones.

Saturday, May 21, 2011

An interesting article “Positive Black Swans” by Tim Harford From Slate

Still, after a few years, Capecchi had decided that Harvard was not for him. Despite great resources, inspiring colleagues and a supportive mentor in Watson, he found the Harvard environment demanded results in too much of a hurry. That was fine, if you wanted to take predictable steps along well-signposted pathways. But Capecchi felt that if you wanted to do great work, to change the world, you had to give yourself space to breathe. Harvard, he thought, had become “a bastion of short-term gratification.” Off he went instead to the University of Utah, where a brand-new department was being set up. He had spotted, in Utah, a Galapagan island on which to develop his ideas.

Mario Capecchi developed the approach for generating knock0ut mice and received the Nobel Prize in Physiology or Medicine 2007.

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2011-05-21 new articles we read this week

Saturday, May 21, 2011

Evolution

  1. Moczek AP. Evolutionary biology: the origins of novelty. Nature. 2011 May 5;473(7345):34-5. PubMed PMID: 21544136.
  2. Tena JJ, Alonso ME, de la Calle-Mustienes E, Splinter E, de Laat W, Manzanares M, Gómez-Skarmeta JL. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation. Nat Commun. 2011;2:310. PubMed PMID: 21556064.
  3. Tirosh I, Reikhav S, Levy AA, Barkai N. A yeast hybrid provides insight into the evolution of gene expression regulation. Science. 2009 May 1;324(5927):659-62. PubMed PMID: 19407207.
  4. Kasowski M, Grubert F, Heffelfinger C, Hariharan M, Asabere A, Waszak SM, Habegger L, Rozowsky J, Shi M, Urban AE, Hong MY, Karczewski KJ, Huber W, Weissman SM, Gerstein MB, Korbel JO, Snyder M. Variation in transcription factor binding among humans. Science. 2010 Apr 9;328(5975):232-5. Epub 2010 Mar 18. PubMed PMID: 20299548; PubMed Central PMCID: PMC2938768.
  5. Landry CR, Lemos B, Rifkin SA, Dickinson WJ, Hartl DL. Genetic properties influencing the evolvability of gene expression. Science. 2007 Jul 6;317(5834):118-21. Epub 2007 May 24. PubMed PMID: 17525304.

Systems Biology

  1. Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K. A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue. Cell. 2011 Apr29;145(3):470-82. PubMed PMID: 21529718; PubMed Central PMCID: PMC3086541.
  2. Liu YY, Slotine JJ, Barabási AL. Controllability of complex networks. Nature. 2011 May 12;473(7346):167-73. PubMed PMID: 21562557.
    • Commentary: Egerstedt M. Complex networks: Degrees of control. Nature. 2011 May 12;473(7346):158-9. PubMed PMID: 21562550.

Genomics

  1. Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature. 2011 May 5;473(7345):43-9. Epub 2011 Mar 23. PubMed PMID: 21441907; PubMed Central PMCID: PMC3088773.
  2. Tasic B, Hippenmeyer S, Wang C, Gamboa M, Zong H, Chen-Tsai Y, Luo L. From the Cover: Site-specific integrase-mediated transgenesis in mice via pronuclear injection. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7902-7. Epub 2011 Apr 4. PubMed PMID: 21464299.

Stem cells

  1. Rao M. Keeping things simple. Nat Methods. 2011 May;8(5):389-90. PubMed PMID: 21527929.
  2. Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7838-43. Epub 2011 Apr 26. PubMed PMID: 21521790.
  3. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011 May 12;473(7346):221-5. Epub 2011 Apr 13. PubMed PMID: 21490598.

Development

  1. Quillien A, Blanco-Sanchez B, Halluin C, Moore JC, Lawson ND, Blader P, Cau E. BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch. Development. 2011 Jun;138(11):2293-302. PubMed PMID: 21558377.
  2. Clanton JA, Shestopalov I, Chen J, Gamse JT. Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran. J Vis Exp. 2011 Apr 28;(50). pii: 2672. doi: 10.3791/2672. PubMed PMID: 21559005.
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2011-05-14 new articles we read this week

Saturday, May 14, 2011

Genomics/ next-generation sequencing

  1. Anders S, Huber W. Differential expression analysis for sequence count data.Genome Biol. 2010;11(10):R106. Epub 2010 Oct 27. PubMed PMID: 20979621.
  2. Gresham D, Boer VM, Caudy A, Ziv N, Brandt NJ, Storey JD, Botstein D. System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae. Genetics. 2011 Jan;187(1):299-317. Epub2010 Oct 13. PubMed PMID: 20944018; PubMed Central PMCID: PMC3018308.
  3. Inaki K, Hillmer AM, Ukil L, Yao F, Woo XY, Vardy LA, Zawack KF, Lee CW, Ariyaratne PN, Chan YS, Desai KV, Bergh J, Hall P, Putti TC, Ong WL, Shahab A, Cacheux-Rataboul V, Karuturi RK, Sung WK, Ruan X, Bourque G, Ruan Y, Liu ET. Transcriptional consequences of genomic structural aberrations in breast cancer.  Genome Res. 2011 May;21(5):676-87. Epub 2011 Apr 5. PubMed PMID: 21467264.

Gene mapping

  1. Chakravarti A. Genomic contributions to Mendelian disease. Genome Res. 2011 May;21(5):643-4. PubMed PMID: 21536725.
  2. Erlich Y, Edvardson S, Hodges E, Zenvirt S, Thekkat P, Shaag A, Dor T, Hannon GJ, Elpeleg O. Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res. 2011 May;21(5):658-64. Epub 2011 Apr 12. PubMed PMID: 21487076.
  3. Lupski JR, Reid JG, Gonzaga-Jauregui C, Rio Deiros D, Chen DC, Nazareth L, Bainbridge M, Dinh H, Jing C, Wheeler DA, McGuire AL, Zhang F, Stankiewicz P, Halperin JJ, Yang C, Gehman C, Guo D, Irikat RK, Tom W, Fantin NJ, Muzny DM, Gibbs RA. Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy. N Engl J Med. 2010 Apr 1;362(13):1181-91. Epub 2010 Mar 10. PubMed PMID: 20220177.
  4. Musunuru K, Pirruccello JP, Do R, Peloso GM, Guiducci C, Sougnez C, Garimella KV, Fisher S, Abreu J, Barry AJ, Fennell T, Banks E, Ambrogio L, Cibulskis K, Kernytsky A, Gonzalez E, Rudzicz N, Engert JC, DePristo MA, Daly MJ, Cohen JC, Hobbs HH, Altshuler D, Schonfeld G, Gabriel SB, Yue P, Kathiresan S. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med. 2010 Dec 2;363(23):2220-7. Epub 2010 Oct 13. PubMed PMID: 20942659; PubMed Central PMCID: PMC3008575.

Systems Biology/ gene regulatory network

  1. Macneil L, Walhout AJ. Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression. Genome Res. 2011 Feb 4. [Epub ahead of print] PubMed PMID: 21324878.
  2. Hakim O, Sung MH, Voss TC, Splinter E, John S, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, de Laat W, Hager GL. Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements. Genome Res. 2011 May;21(5):697-706. Epub 2011 Apr 6. PubMed PMID: 21471403.

Stem cells

  1. Focus on stem cells. Nat Cell Biol. 2011 May;13(5):489. PubMed PMID: 21540843.
  2. Ng HH, Surani MA. The transcriptional and signalling networks of pluripotency. Nat Cell Biol. 2011 May;13(5):490-6. PubMed PMID: 21540844.
  3. Wu SM, Hochedlinger K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol. 2011 May;13(5):497-505. PubMed PMID: 21540845.
  4. Jones DL, Rando TA. Emerging models and paradigms for stem cell ageing. NatCell Biol. 2011 May;13(5):506-12. PubMed PMID: 21540846.
  5. Fuchs E, Horsley V. Ferreting out stem cells from their niches. Nat Cell Biol.2011 May;13(5):513-8. PubMed PMID: 21540847.
  6. Barrero MJ, Izpisua Belmonte JC. iPS cells forgive but do not forget. Nat CellBiol. 2011 May;13(5):523-5. PubMed PMID: 21540851.
  7. Ohi Y, Qin H, Hong C, Blouin L, Polo JM, Guo T, Qi Z, Downey SL, Manos PD, Rossi DJ, Yu J, Hebrok M, Hochedlinger K, Costello JF, Song JS, Ramalho-Santos M. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol. 2011 May;13(5):541-9. Epub 2011 Apr 17. PubMedPMID: 21499256.

Eye disease

  1. Shu X, Zeng Z, Gautier P, Lennon A, Gakovic M, Cheetham ME, Patton EE, Wright AF. Knockdown of the Zebrafish Ortholog of the Retinitis Pigmentosa 2 (RP2) Gene Results in Retinal Degeneration. Invest Ophthalmol Vis Sci. 2011 May5;52(6):2960-6. Print 2011. PubMed PMID: 21282572.
  2. Pinazo-Durán MD, Pons-Vázquez S, Gallego-Pinazo R, Galbis Estrada C, Zanón-Moreno V, Vila Bou V, Sanz Solana P. Thyroid hormone deficiency disrupts rat eye neurodevelopment. Brain Res. 2011 Apr 9. [Epub ahead of print] PubMedPMID: 21529787.

Zebrafish

  1. Nava SS, An S, Hamil T. Visual detection of UV cues by adult zebrafish (Danio rerio). J Vis. 2011 May 4;11(6). pii: 2. doi: 10.1167/11.6.2. Print 2011. PubMed PMID: 21543523.
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Common Faults in Human Thought

Thursday, May 12, 2011

I just come across these two excellent articles that point out many wrong ideas that we can have in life. Interestingly, I find most are also our attitude towards scientific research. Try not to do that.

Top 10 Common Faults in Human Thought

10 More Common Faults in Human Thought

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A Biologist’s Mother’s Day Song

Sunday, May 8, 2011

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2011-05-08 new articles we read this week

Sunday, May 8, 2011

Genomics

  1. Nagano T, Fraser P. No-Nonsense Functions for Long Noncoding RNAs. Cell. 2011 Apr 15;145(2):178-81. PubMed PMID: 21496640.
  2. Mak HC. John storey. Nat Biotechnol. 2011 Apr;29(4):331-3. PubMed PMID: 21478851.
    • A nice discussion by John Storey on the challenges of normalization and analysis of next generation sequencing data for RNA-Seq.

Systems biology

  1. Oleksiuk O, Jakovljevic V, Vladimirov N, Carvalho R, Paster E, Ryu WS, Meir Y, Wingreen NS, Kollmann M, Sourjik V. Thermal robustness of signaling in bacterial
    chemotaxis. Cell. 2011 Apr 15;145(2):312-21. PubMed PMID: 21496648.

Development

  1. McKay R. Developmental biology: Remarkable role for the placenta. Nature. 2011 Apr 21;472(7343):298-9. PubMed PMID: 21512563.

Funding

  1. Samuel Reich E, Semeniuk I, Tollefson J, Wadman M. US budget a taste ofbattles to come. Nature. 2011 Apr 21;472(7343):267-9. PubMed PMID: 21512542.

Reviewing

  1. Ploegh H. End the wasteful tyranny of reviewer experiments. Nature. 2011 Apr 28;472(7344):391. PubMed PMID: 21525890.

Ethical, Legal and Social Issues

  1. Dugdale LS, Ridenour AA. Making sense of the Roman Catholic directive to extend life indefinitely. Hastings Cent Rep. 2011 Mar-Apr;41(2):28-9. PubMed PMID: 21495514.
  2. Rennie S. Viewing research participation as a moral obligation: in whose interests? Hastings Cent Rep. 2011 Mar-Apr;41(2):40-7. PubMed PMID: 21495516.
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2011-04-23 new articles we read this week

Saturday, April 23, 2011

Education

Nature Magazine has published a series of papers that discuss “The Future of The PhD“. Another discussion of the challenges that PhD students encounter and a debate on whether a doctoral degree should be a training for job or a training for scientific thinking. The discussions from the readers under each article on the website are also interesting.

  1. Fix the PhD. Nature. 2011 Apr 21;472(7343):259-260. PubMed PMID: 21512527.
  2. Cyranoski D, Gilbert N, Ledford H, Nayar A, Yahia M. Education: The PhD factory. Nature. 2011 Apr 21;472(7343):276-279. PubMed PMID: 21512548.
  3. McCook A. Education: Rethinking PhDs. Nature. 2011 Apr 21;472(7343):280-282.PubMed PMID: 21512549.
  4. Gosling R, Tickle C, Running SW, Tandong Y, Dinnyes A, Osowole AA, Cule E. Seven ages of the PhD. Nature. 2011 Apr 21;472(7343):283-286. PubMed PMID: 21512550.
  5. Taylor M. Reform the PhD system or close it down. Nature. 2011 Apr 21;472(7343):261. PubMed PMID: 21512530.
  6. Fiske P. What is a PhD really worth?. Nature 2011 Apr 22;472(7343):381
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2011-04-16 New articles we read this week

Saturday, April 16, 2011

Development

  1. Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature. 2011 Apr 7;472(7341):51-6. PubMed PMID: 21475194.
    1. Commentary: Ali RR, Sowden JC. Regenerative medicine: DIY eye. Nature. 2011 Apr 7;472(7341):42-3. PubMed PMID: 21475187.
    2. News report from the Telegraph. “Scientists grow ’embryonic eye’ in test tube“.
    • A whole eye cup with properly laminated retina and RPE can spontaneously generate from mouse embryonic stem cell culture!

Eye disease

  1. Morris AC, Forbes-Osborne MA, Pillai LS, Fadool JM. Microarray Analysis of XOPS-mCFP Zebrafish Retina Identifies Genes Associated with Rod Photoreceptor Degeneration and Regeneration. Invest Ophthalmol Vis Sci. 2011 Apr6;52(5):2255-66. Print 2011 Apr. PubMed PMID: 21217106.
  2. Stujenske JM, Dowling JE, Emran F. The Bugeye Mutant Zebrafish Exhibits Visual Deficits that Arise with the Onset of an Enlarged Eye Phenotype. Invest Ophthalmol Vis Sci. 2011 Apr 1. [Epub ahead of print] PubMed PMID: 21460263.

Retinal development

  1. Glaschke A, Weiland J, Del Turco D, Steiner M, Peichl L, Glösmann M. Thyroid hormone controls cone opsin expression in the retina of adult rodents. JNeurosci. 2011 Mar 30;31(13):4844-51. PubMed PMID: 21451022.

Ethical, Social and Legal Issues

  1. Hayden EC. Patent dispute threatens US Alzheimer’s research. Nature. 2011 Apr 7;472(7341):20. PubMed PMID: 21475170.

Education

  1. Nayar A. Developing world: educating India. Nature. 2011 Apr 7;472(7341):24-6. PubMed PMID: 21475172.

Cancer

  1. Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D, Muthuswamy L, Krasnitz A, McCombie WR, Hicks J, Wigler M. Tumour evolution inferred by single-cell sequencing. Nature. 2011 Apr7;472(7341):90-4. Epub 2011 Mar 13. PubMed PMID: 21399628.

Neurobehavior

  1. Liu Y, Jiang Y, Si Y, Kim JY, Chen ZF, Rao Y. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. 2011 Apr 7;472(7341):95-9. Epub 2011 Mar 23. PubMed PMID: 21441904.
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2011-04-10 new articles we read this week

Sunday, April 10, 2011

Vision

  1. Standfuss J, Edwards PC, D’Antona A, Fransen M, Xie G, Oprian DD, Schertler GF. The structural basis of agonist-induced activation in constitutively active rhodopsin. Nature. 2011 Mar 31;471(7340):656-60. Epub 2011 Mar 9. PubMed PMID: 21389983.

Genetics

  1. Hurst LD. Molecular genetics: The sound of silence. Nature. 2011 Mar 31;471(7340):582-3. PubMed PMID: 21455166.
    • How silence mutations can cause disease? One more example from the study of Crohn’s disease.
  2. Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6. PubMed PMID: 21436445.
    • Commentary: Duncan MK. Development. A new focus on RNA in the lens. Science. 2011 Mar 25;331(6024):1523-4. PubMed PMID: 21436425.
  3. Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nat Methods. 2011 Apr;8(4):341-6. Epub 2011 Mar 6. PubMed PMID: 21378980.

 

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2011-04-02 New articles we read this week

Saturday, April 2, 2011

Neuroscience

  1. Rothenaigner I, Krecsmarik M, Hayes JA, Bahn B, Lepier A, Fortin G, Götz M, Jagasia R, Bally-Cuif L. Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate. Development. 2011Apr;138(8):1459-69. Epub 2011 Mar 2. PubMed PMID: 21367818.

Eye disease

  1. Leung CK, Weinreb RN, Li ZW, Liu S, Lindsey JD, Choi N, Liu L, Cheung CY, Ye C, Qiu K, Chen LJ, Yung WH, Crowston JG, Pu M, So KF, Pang CP, Lam DS. Long-term in vivo imaging and measurement of dendritic shrinkage of retinal ganglion cells.Invest Ophthalmol Vis Sci. 2011 Mar 1;52(3):1539-47. Print 2011. PubMed PMID:21245394.

Retina

  1. Cederlund ML, Morrissey ME, Baden T, Scholz D, Vendrell V, Lagnado L, Connaughton VP, Kennedy BN. Zebrafish Tg(7.2mab21l2:EGFP)ucd2 Transgenics Reveal a Unique Population of Retinal Amacrine Cells. Invest Ophthalmol Vis Sci. 2011Mar 1;52(3):1613-21. Print 2011. PubMed PMID: 21051702.

Genomics

  1. Thompson JF, Milos PM. The properties and applications of single-molecule DNA sequencing. Genome Biol. 2011 Feb 24;12(2):217. [Epub ahead of print] PubMedPMID: 21349208.
  2. Commentary: Furlong EE. Molecular biology: A fly in the face of genomics. Nature. 2011 Mar 24;471(7339):458-9. PubMed PMID: 21430772.
    1. Kharchenko PV, Alekseyenko AA, Schwartz YB, Minoda A, Riddle NC, Ernst J, Sabo PJ, Larschan E, Gorchakov AA, Gu T, Linder-Basso D, Plachetka A, Shanower G, Tolstorukov MY, Luquette LJ, Xi R, Jung YL, Park RW, Bishop EP, Canfield TK, Sandstrom R, Thurman RE, MacAlpine DM, Stamatoyannopoulos JA, Kellis M, Elgin SC, Kuroda MI, Pirrotta V, Karpen GH, Park PJ. Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature. 2011 Mar 24;471(7339):480-5. Epub 2010 Dec 22. PubMed PMID: 21179089.
    2. Graveley BR, Brooks AN, Carlson JW, Duff MO, Landolin JM, Yang L, Artieri CG, van Baren MJ, Boley N, Booth BW, Brown JB, Cherbas L, Davis CA, Dobin A, Li R, Lin W, Malone JH, Mattiuzzo NR, Miller D, Sturgill D, Tuch BB, Zaleski C, Zhang D, Blanchette M, Dudoit S, Eads B, Green RE, Hammonds A, Jiang L, Kapranov P, Langton L, Perrimon N, Sandler JE, Wan KH, Willingham A, Zhang Y, Zou Y, Andrews J, Bickel PJ, Brenner SE, Brent MR, Cherbas P, Gingeras TR, Hoskins RA, Kaufman TC, Oliver B, Celniker SE. The developmental transcriptome of Drosophila melanogaster. Nature. 2011 Mar 24;471(7339):473-9. Epub 2010 Dec 22. PubMed PMID: 21179090.
    3. Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24;471(7339):527-31. PubMed PMID: 21430782.

Cancer

  1. Buchen L. Cancer: Missing the mark. Nature. 2011 Mar 24;471(7339):428-32.PubMed PMID: 21430749.
  2. Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, Bernstein BE, Drier Y, Fonseca R, Gabriel SB, Hofmeister CC, Jagannath S, Jakubowiak AJ, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins LM, Onofrio R, Pugh TJ, Rajkumar SV, Ramos AH, Siegel DS, Sivachenko A, Stewart AK, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn WC, Garraway LA, Meyerson M, Lander ES, Getz G, Golub
    TR. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011 Mar 24;471(7339):467-72. PubMed PMID: 21430775.
  3. White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E,  Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 2011 Mar 24;471(7339):518-22. PubMed PMID: 21430780.
  4. Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 2011 Mar 24;471(7339):513-7. PubMed PMID: 21430779.

Reproduction

  1. Seandel M, Rafii S. Reproductive biology: In vitro sperm maturation. Nature.2011 Mar 24;471(7339):453-5. PubMed PMID: 21430767.

Disease gene mapping

  1. Piggins HD. Schizophrenia: Zooming in on a gene. Nature. 2011 Mar 24;471(7339):455-6. PubMed PMID: 21430769.

Development

  1. Rossant J. Developmental biology: A mouse is not a cow. Nature. 2011 Mar 24;471(7339):457-8. PubMed PMID: 21430771.
  2. Mou C, Pitel F, Gourichon D, Vignoles F, Tzika A, Tato P, Yu L, Burt DW, Bed’hom B, Tixier-Boichard M, Painter KJ, Headon DJ. Cryptic patterning of avian skin confers a developmental facility for loss of neck feathering. PLoS Biol. 2011 Mar;9(3):e1001028. Epub 2011 Mar 15. PubMed PMID: 21423653; PubMed Central PMCID: PMC3057954.

Evolution

  1. Woods RJ, Barrick JE, Cooper TF, Shrestha U, Kauth MR, Lenski RE. Second-order selection for evolvability in a large Escherichia coli population. Science. 2011 Mar 18;331(6023):1433-6. PubMed PMID: 21415350.
  2. Philippe H, Brinkmann H, Lavrov DV, Littlewood DT, Manuel M, Wörheide G, Baurain D. Resolving difficult phylogenetic questions: why more sequences are not enough. PLoS Biol. 2011 Mar;9(3):e1000602. Epub 2011 Mar 15. PubMed PMID: 21423652; PubMed Central PMCID: PMC3057953.

Medicine

  1. Physicians as guardians of genetic knowledge. Lancet. 2011 Mar 19;377(9770):967. PubMed PMID: 21420539.
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