Tuesday, January 17, 2017
Evolution Gonzalez P, Uhlinger KR, Lowe CJ. The Adult Body Plan of Indirect Developing Hemichordates Develops by Adding a Hox-Patterned Trunk to an Anterior Larval Territory. Curr Biol. 2016 Dec 7. pii: S0960-9822(16)31273-8. doi: 10.1016/j.cub.2016.10.047. [Epub ahead of print] PubMed PMID: 27939313. Hejnol A, Vellutini BC. Larval Evolution: I’ll Tail You Later…. Curr Biol. 2017 […]
Genomics Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013 Oct 21;14(10):R115. [Epub ahead of print] PubMed PMID: 24138928. News coverage: Scientists Discover New Biological Clock With Age-Measuring Potential News: FDA Tells Google-Backed 23andMe to Halt DNA Test Service Evolution Kolb AW, Ané C, Brandt CR. Using HSV-1 Genome Phylogenetics to Track Past Human […]
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Tagged 23andMe, AIDS, axon guidance, evolution, FDA, HIV, HSV, locomotor, methylation, neuroscience, zebrafish
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Sunday, September 29, 2013
Stem cells Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature. 2013 Sep 11. doi: 10.1038/nature12586. [Epub ahead of print] PubMed PMID: 24025773. Commentary: De Los Angeles […]
Stem cells Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18. PubMed PMID: […]
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Tagged brain, cone photoreceptors, CRISPR, CRISPR-CAS, induced pluripotent stem cells, iPSCs, memory, mitochondrial eve, neuroscience, olfaction, regeneration, retina, small molecules, stem cells, vision, Y-chromosomal adam, zebrafish
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These days many cherish “hypothesis-driven” research and trash everything that is observational, exploratory and non-translational. And yet the hypothesis in many research is “post-research” hypothesis. The “hypothesis” itself is also often generated for the sake of having an hypothesis; the essence of the research can still be exploratory. So when funding is getting scarce and […]
Saturday, November 20, 2010
Disease Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu P, Hickstein DD. brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5. Epub 2010 Oct 25. PubMed PMID: 20974951. Jain S, Heutink P. From single genes to gene networks: high-throughput-high-content screening for neurological disease. […]
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Thursday, September 2, 2010
I suggest we read a paper recently published in Science. The title is “Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa”. Retinal pigmentosa is so far found to be caused by diverse mutations in 44 genes. Patients with this diease will irreversibly lose their vision, as rod photoreceptors will die early and cone photoreceptor […]
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Sunday, September 20, 2009
We will all read two short articles about Cystic Fibrosis: Couzin-Frankel J. The promise of a cure: 20 years and counting. Science. 2009 Jun 19;324(5934):1504-7. Pearson H. One gene, twenty years. Nature. 2009 Jul 9;460(7252):164-9. Each one of us will then pick one of the following topics, elaborate the discussion by reading an additional latest […]