Saturday, January 14, 2012
Retinal Development Kwan KM, Otsuna H, Kidokoro H, Carney KR, Saijoh Y, Chien CB. A complex choreography of cell movements shapes the vertebrate eye. Development. 2012 Jan;139(2):359-72. PubMed PMID: 22186726. Morgan JL, Soto F, Wong RO, Kerschensteiner D. Development of cell type-specific connectivity patterns of converging excitatory axons in the retina. Neuron. 2011 Sep 22;71(6):1014-21. […]
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Also tagged education, evolution, genetics, genomics, neuroscience, retinal development, stem cells, systems biology, vision, zebrafish
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I recently visited the Eye Hospital at Wenzhou Medical College, where they have very good research infrastructure that has integrated various aspects of basic and clinical ophthalmology research together. I gave two talks over there and had a great interaction […]
Saturday, December 3, 2011
Medicine There seems to be a new effective drug for Cystic Fibrosis! Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Dřevínek P, Griese M, McKone EF, Wainwright CE, Konstan MW, Moss R, Ratjen F, Sermet-Gaudelus I, Rowe SM, Dong Q, Rodriguez S, Yen K, Ordoñez C, Elborn JS; VX08-770-102 Study Group. A CFTR […]
Sunday, November 20, 2011
Medical Research *These two articles point out the problems of using animal models for research if the goal is to extract translational values and how mouse model, the gold standard for disease research, can actually be a poor reference standard because of the ways we want to standardize the biological tool for testing. Lynch VJ. […]
Thursday, November 17, 2011
I just come across with this article in Slate Magazine “The Mouse Trap – The dangers of using one lab animal to study every disease.” that talks in great details about the limitation of using animal model to look for new drugs to treat human diseases. For example, the control healthy mouse can actually be […]
Thursday, November 3, 2011
The genome sequence of the naked mole rat is published recently (Kim et al., 2011) ! This is an amazing creature that lives almost up to 30 years in captivity, 9 times longer than mice. At the same time they do not seem to suffer from cancer or a decline in fertility (Buffenstein 2008). I […]
Saturday, October 29, 2011
Development Lander AD. Pattern, growth, and control. Cell. 2011 Mar 18;144(6):955-69. Review. PubMed PMID: 21414486; PubMed Central PMCID: PMC3128888. Braendle C, Felix MA. The other side of phenotypic plasticity: a developmental system that generates an invariant phenotype despite environmental variation. J Biosci. 2009 Oct;34(4):543-51. Review. PubMed PMID: 19920340. Noordermeer D, Leleu M, Splinter E, Rougemont […]