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2010-11-13 Articles we read this week

Saturday, November 13, 2010

Retina & regeneration

  1. Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T. CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors. Genome Res. 2010 Nov;20(11):1512-25. Epub 2010 Aug 6. PubMed PMID: 20693478.
  2. Ramachandran R, Fausett BV, Goldman D. Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol. 2010 Nov;12(11):1101-7. Epub 2010 Oct 10. PubMed PMID: 20935637; PubMed Central PMCID: PMC2972404.
  3. Choy SW, Cheng CW, Lee ST, Li VW, Hui MN, Hui CC, Liu D, Cheng SH.  A cascade of irx1a and irx2a controls shh expression during retinogenesis. Dev Dyn. 2010 Nov 2;. [Epub ahead of print]
  4. Choi JH, Law MY, Chien CB, Link BA, Wong RO. In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. Neural Dev. 2010 Nov 2;5(1):29. [Epub ahead of print] PubMed PMID: 21044295.

Development

  1. Apodaca G. Opening ahead: early steps in lumen formation revealed. Nat Cell Biol. 2010 Nov;12(11):1026-8. PubMed PMID: 21045801.
  2. Morris JA, Royall JJ, Bertagnolli D, Boe AF, Burnell JJ, Byrnes EJ, Copeland C, Desta T, Fischer SR, Goldy J, Glattfelder KJ, Kidney JM, Lemon T, Orta GJ, Parry SE, Pathak SD, Pearson OC, Reding M, Shapouri S, Smith KA, Soden C, Solan BM, Weller J, Takahashi JS, Overly CC, Lein ES, Hawrylycz MJ, Hohmann JG, Jones AR. Divergent and nonuniform gene expression patterns in mouse brain. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19049-54. Epub 2010 Oct 18. PubMed PMID: 20956311.
  3. Pedersen MT, Helin K. Histone demethylases in development and disease. Trends  Cell Biol. 2010 Nov;20(11):662-71. Epub 2010 Sep 20. PubMed PMID: 20863703.

Gene regulatory network & Systems biology

  1. Cotterell J, Sharpe J. An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients. Mol Syst Biol. 2010 Nov 2;6:425. PubMed PMID: 21045819.
  2. Salazar C, Brümmer A, Alberghina L, Höfer T. Timing control in regulatory networks by multisite protein modifications. Trends Cell Biol. 2010 Nov;20(11):634-41. Epub 2010 Sep 23. PubMed PMID: 20869247.

Disease

  1. Van Broeckhoven C. The future of genetic research on neurodegeneration. Nat Med. 2010 Nov;16(11):1215-7. Epub 2010 Sep 21. PubMed PMID: 21052076.
  2. Jucker M. The benefits and limitations of animal models for translational research in neurodegenerative diseases. Nat Med. 2010 Nov;16(11):1210-4. Epub 2010 Sep 21. PubMed PMID: 21052075.
  3. Haass C. Initiation and propagation of neurodegeneration. Nat Med. 2010 Nov;16(11):1201-4. Epub 2010 Sep 21. PubMed PMID: 21052073.
  4. Jacobson SG, Cideciyan AV. Treatment possibilities for retinitis pigmentosa. N Engl J Med. 2010 Oct 21;363(17):1669-71. PubMed PMID: 20961252.
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2010-11-06 Articles we read this week

Saturday, November 6, 2010

Immunity

  1. Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC. Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proc Natl Acad Sci U S A. 2010 Nov 2. [Epub ahead of print] PubMed PMID: 21045130.

Medicine

  1. Zrenner E, Bartz-Schmidt KU, Benav H, Besch D, Bruckmann A, Gabel VP, Gekeler F, Greppmaier U, Harscher A, Kibbel S, Koch J, Kusnyerik A, Peters T, Stingl K, Sachs H, Stett A, Szurman P, Wilhelm B, Wilke R. Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc Biol Sci. 2010 Nov 3. [Epub ahead of print] PubMed PMID: 21047851.]

Gene regulatory network

  1. Kuo D, Licon K, Bandyopadhyay S, Chuang R, Luo C, Catalana J, Ravasi T, Tan K, Ideker T.   Coevolution within a transcriptional network by compensatory trans and cis mutations. Genome Res. 2010 Oct 26;. [Epub ahead of print]

Genomics

  1. Human genome: Genomes by the thousand. Nature. 2010 Oct 28;467(7319):1026-7. PubMed PMID: 20981067.
  2. Nielsen R. Genomics: In search of rare human variants. Nature. 2010 Oct 28;467(7319):1050-1. PubMed PMID: 20981085.
  3. Luebeck EG. Cancer: Genomic evolution of metastasis. Nature. 2010 Oct 28;467(7319):1053-5. PubMed PMID: 20981088.
  4. 1000 Genomes Project Consortium, Durbin RM, Abecasis GR, Altshuler DL, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME, McVean GA. A map of human genome variation from population-scale sequencing. Nature. 2010 Oct 28;467(7319):1061-73. PubMed PMID: 20981092.
  5. Lane N, Martin W. The energetics of genome complexity. Nature. 2010 Oct 21;467(7318):929-34. PubMed PMID: 20962839.

Development

  1. Varner VD, Voronov DA, Taber LA. Mechanics of head fold formation: investigating tissue-level forces during early development. Development. 2010 Nov;137(22):3801-11. Epub 2010 Oct 7. PubMed PMID: 20929950.

Retina

  1. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990 Feb 22;292(4):497-523. PubMed PMID: 2324310.

Behaviour

  1. Cachat J, Stewart A, Grossman L, Gaikwad S, Kadri F, Chung KM, Wu N, Wong K, Roy S, Suciu C, Goodspeed J, Elegante M, Bartels B, Elkhayat S, Tien D, Tan J, Denmark A, Gilder T, Kyzar E, Dileo J, Frank K, Chang K, Utterback E, Hart P, Kalueff AV. Measuring behavioral and endocrine responses to novelty stress in adult zebrafish. Nat Protoc. 2010 Oct;5(11):1786-99. Epub 2010 Oct 14. PubMed PMID: 21030954.

Neuroscience

  1. Pyc MA, Rawson KA. Why testing improves memory: mediator effectiveness hypothesis. Science. 2010 Oct 15;330(6002):335. PubMed PMID: 20947756.

Imaging

  1. Ariga J, Walker SL, Mumm JS. Multicolor Time-lapse Imaging of Transgenic Zebrafish: Visualizing Retinal Stem Cells Activated by Targeted Neuronal Cell Ablation. J Vis Exp. 2010 Sep 20;(43). pii: 2093. doi: 10.3791/2093. PubMed PMID: 20972390.

Stem cells

  1. Pera MF. Defining pluripotency. Nat Methods. 2010 Nov;7(11):885-7. PubMed PMID: 21030963.
  2. Verzi MP, Shivdasani RA. Stem cells: The intestinal-crypt casino. Nature. 2010 Oct 28;467(7319):1055-6. PubMed PMID: 20981089.

Chromatin remodeling

  1. Saladi SV, Keenen B, Marathe HG, Qi H, Chin KV, de la Serna IL. Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer. 2010 Oct 22;9(1):280. [Epub ahead of print] PubMed PMID: 20969766.

Cdk5

  1. He L, Zhang Z, Yu Y, Ahmed S, Cheung NS, Qi RZ. The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein. Cell Mol Life Sci. 2010 Oct 26. [Epub ahead of print] PubMed PMID: 20976519.

Ethics, Society and Legal Issues

  1. Udesky L. The ethics of direct-to-consumer genetic testing. Lancet. 2010 Oct 23;376(9750):1377-8. PubMed PMID: 20979325.
  2. Macilwain C. Scientists vs engineers: this time it’s financial. Nature. 2010 Oct 21;467(7318):885. PubMed PMID: 20962798.

Funding

  1. Brumfiel G. UK science funds in limbo. Nature. 2010 Oct 21;467(7318):894. PubMed PMID: 20962813.
  2. Gilbert N. Ireland defends research from cuts. Nature. 2010 Oct 21;467(7318):895. PubMed PMID: 20962814.
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2010-10-31 new articles we read this week

Monday, November 1, 2010

Genetics & Genomics

  1. Huang N, Lee I, Marcotte EM, Hurles ME. Characterising and predicting haploinsufficiency in the human genome. PLoS Genet. 2010 Oct 14;6(10):e1001154. PubMed PMID: 20976243; PubMed Central PMCID: PMC2954820.
  2. Sigurdsson MI, Jamshidi N, Steingrimsson E, Thiele I, Palsson BO. A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. BMC Syst Biol. 2010 Oct 19;4(1):140. [Epub ahead of print] PubMed PMID: 20959003.
  3. Pinna A, Soranzo N, de la Fuente A. From knockouts to networks: establishing direct cause-effect relationships through graph analysis. PLoS One. 2010 Oct 11;5(10):e12912. PubMed PMID: 20949005; PubMed Central PMCID: PMC2952592.

Retina & Eye

  1. Uribe RA, Gross JM. Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics. Development. 2010 Nov;137(22):3763-74. Epub 2010 Oct 13. PubMed PMID: 20943708.
  2. Davis DM, Dyer MA. Retinal progenitor cells, differentiation, and barriers to cell cycle reentry. Curr Top Dev Biol. 2010;93:175-88. PubMed PMID: 20959166.
  3. Fuhrmann S. Eye morphogenesis and patterning of the optic vesicle. Curr Top Dev Biol. 2010;93:61-84. PubMed PMID: 20959163; PubMed Central PMCID: PMC2958684.
  4. Kumar JP. Retinal determination the beginning of eye development. Curr Top Dev Biol. 2010;93:1-28. PubMed PMID: 20959161.
  5. Donovan M, Doonan F, Cotter TG. Differential roles of ERK1/2 and JNK in Retinal Development and Degeneration. J Neurochem. 2010 Oct 15. doi: 10.1111/j.1471-4159.2010.07056.x. [Epub ahead of print] PubMed PMID: 20950336.

Stem cells

  1. Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F, Ng HH. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature. 2010 Oct 17. [Epub ahead of print] PubMed PMID: 20953172.

Systems Biology

  1. Chang RL, Xie L, Xie L, Bourne PE, Palsson BØ. Drug off-target effects predicted using structural analysis in the context of a metabolic network model.  PLoS Comput Biol. 2010 Sep 23;6(9):e1000938. PubMed PMID: 20957118; PubMed Central PMCID: PMC2950675.

Zebrafish

  1. Hortopan GA, Dinday MT, Baraban SC. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J Neurosci. 2010 Oct 13;30(41):13718-28. PubMed PMID: 20943912; PubMed Central PMCID: PMC2962868.
  2. Mara A, Holley SA. Oscillators and the emergence of tissue organization during zebrafish somitogenesis. Trends Cell Biol. 2007 Dec;17(12):593-9. Epub 2007 Nov 7. Review. PubMed PMID: 17988868.
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2010-10-23 articles we read this week

Monday, October 25, 2010

Eye diseases

  1. Moiseyev G, Nikolaeva O, Chen Y, Farjo K, Takahashi Y, Ma JX. Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17551-6. Epub 2010 Sep 27. PubMed PMID: 20876139.
  2. Hampton T. Genetic research provides insights into age-related macular degeneration. JAMA. 2010 Oct 13;304(14):1541-3. PubMed PMID: 20940375.

Stem cells

  1. Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17668-73. Epub 2010 Sep 27. PubMed PMID: 20876107.
  2. Stadtfeld M, Hochedlinger K. Induced pluripotency: history, mechanisms, and pplications. Genes Dev. 2010 Oct 15;24(20):2239-63. PubMed PMID: 20952534.

Medicine

  1. Hall WD, Mathews R, Morley KI. Being More Realistic about the Public Health Impact of Genomic Medicine. PLoS Med. 2010 Oct 12;7(10). pii: e1000347. PubMed PMID: 20967240.
  2. Lares MR, Rossi JJ, Ouellet DL. RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol. 2010 Nov;28(11):570-9. Epub 2010 Sep 15. PubMed PMID: 20833440.
  3. Murray AB, Carson MJ, Morris CA, Beckwith J. Illusions of scientific legitimacy: misrepresented science in the direct-to-consumer genetic-testing marketplace. Trends Genet. 2010 Sep 7. [Epub ahead of print] PubMed PMID: 20828856.

Irx

  1. Yang ZQ, Liu G, Bollig-Fischer A, Giroux CN, Ethier SP. Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer. Cancer Res. 2010 Oct 12. [Epub ahead of print] PubMed PMID: 20940404.

Education

  1. Kazilek C. Ask a biologist: bringing science to the public. PLoS Biol. 2010 Oct 12;8(10). pii: e1000458. PubMed PMID: 20967230.

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How to publish like a pro

Tuesday, October 19, 2010

There is an interesting article, “Publish like a pro“, in this issue of Nature that talks about how to write papers and plan your project efficiently. Several of us who are writing a manuscript of some sort are already using several tricks, including having a paper plan right at the beginning and having multiple revisions. It does not hurt to read the article and refresh your memory.

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2010-10-16 Articles we read this week

Saturday, October 16, 2010

Delta-Notch

  1. Cohen M, Georgiou M, Stevenson NL, Miodownik M, Baum B. Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell. 2010 Jul 20;19(1):78-89. PubMed PMID: 20643352.

Medicine and ethics

  1. Yurkiewicz S.  The Prospects for Personalized Medicine. Hastings Cent Rep. 2010; 40:14-16.
  2. Fleck LM. Personalized Medicine’s Ragged Edge. 2010; 40:16-18.
  3. Gilbert S. Personalized Cancer Care in an Age of Anxiety. 2010; 40: 18-21.
  4. Tillinghast GW. Microarrays in the clinic. Nat Biotechnol. 2010.Aug;28(8):810-2. PubMed PMID: 20697405.
  5. Shi L, MAQC Consortium. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based  predictive models. Nat Biotechnol. 2010 Aug;28(8):827-38. Epub 2010 Jul 30. PubMed PMID: 20676074.

Systems biology

  1. Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW. Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol. 2010 Oct 5;6:417. PubMed PMID: 20924352.
  2. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. A fast, robust and tunable synthetic gene oscillator. Nature. 2008 Nov 27;456(7221):516-9. Epub 2008 Oct 29. PubMed PMID: 18971928.
  3. Tigges M, Marquez-Lago TT, Stelling J, Fussenegger M. A tunable synthetic mammalian oscillator. Nature. 2009 Jan 15;457(7227):309-12. PubMed PMID: 19148099.
  4. Cağatay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM. Architecture-dependent noise discriminates functionally analogous differentiation circuits. Cell. 2009 Oct 30;139(3):512-22. Epub 2009 Oct 22. PubMed PMID:19853288.
  5. Bollenbach T, Kishony R. Quiet gene circuit more fragile than its noisy peer. Cell. 2009 Oct 30;139(3):460-1. PubMed PMID: 19879833.
  6. Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE Jr. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 4;321(5885):126-9. PubMed PMID: 18599789; PubMed Central PMCID: PMC2728800.
  7. Novák B, Tyson JJ. Design principles of biochemical oscillators. Nat Rev Mol Cell Biol. 2008 Dec;9(12):981-91. Epub 2008 Oct 30. Review. PubMed PMID: 18971947; PubMed Central PMCID: PMC2796343.

Imaging

  1. Swoger J, Muzzopappa M, López-Schier H, Sharpe J. 4D retrospective lineage tracing using SPIM for zebrafish organogenesis studies. J Biophotonics. 2010 Oct 5. [Epub ahead of print] PubMed PMID: 20925108.

Zebrafish

  1. Kim J, Wu Q, Zhang Y, Wiens KM, Huang Y, Rubin N, Shimada H, Handin RI, Chao MY, Tuan TL, Starnes VA, Lien CL. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17206-10. Epub 2010 Sep 21. PubMed PMID: 20858732.
  2. Dlugos CA, Brown SJ, Rabin RA. Gender differences in ethanol-induced behavioral sensitivity in zebrafish. Alcohol. 2010 Sep 28. [Epub ahead of print]PubMed PMID: 20880661.

Development

  1. Fujimoto T, Nishimura T, Goto-Kazeto R, Kawakami Y, Yamaha E, Arai K. Sexual dimorphism of gonadal structure and gene expression in germ cell-deficient loach, a teleost fish. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17211-6. Epub 2010 Sep 20. PubMed PMID: 20855617.

Stem cells

  1. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL.Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. N Engl J Med. 2010 Jul 21. [Epub ahead of print] PubMed PMID: 20660394.

Vision

  1. Demb JB, Brainard DH. Vision: Neurons show their true colours. Nature. 2010 Oct 7;467(7316):670-1. PubMed PMID: 20930837.
  2. Field GD, Gauthier JL, Sher A, Greschner M, Machado TA, Jepson LH, Shlens J, Gunning DE, Mathieson K, Dabrowski W, Paninski L, Litke AM, Chichilnisky EJ.Functional connectivity in the retina at the resolution of photoreceptors. Nature. 2010 Oct 7;467(7316):673-7. PubMed PMID: 20930838; PubMed Central PMCID: PMC2953734.
  3. Satoh AK, Xia H, Yan L, Liu CH, Hardie RC, Ready DF. Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors. Neuron. 2010 Sep 23;67(6):997-1008. PubMed PMID: 20869596; PubMed Central PMCID: PMC2946946.

General

  1. Ørom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, Lai F, Zytnicki M, Notredame C, Huang Q, Guigo R, Shiekhattar R. Long noncoding RNAs with enhancer-like function in human cells. Cell. 2010 Oct 1;143(1):46-58. PubMed PMID: 20887892.
  2. Collins F. Scientists need a shorter path to research freedom. Nature. 2010 Oct 7;467(7316):635. PubMed PMID: 20930798.
  3. Ledford H. Garage biotech: Life hackers. Nature. 2010 Oct 7;467(7316):650-2. PubMed PMID: 20930820.
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Peter Hollenbeck’s interview in Current Biology

Thursday, October 14, 2010

See our neighbour’s interview here.

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Lasker Awards 2010

Tuesday, October 12, 2010

I am preparing these reading materials for my class and strongly believe that you would be interested in and benefited by reading these articles.

These are a series of articles published in this issue of Nature Medicine about this year’s Lasker Awards, the most prestigious award for biomedical research in this country.

There is an introductory article written by the Chairman of the Awards Jury, Joseph Goldstein, on the importance of the findings and a great summary of wisdom on doing great research; this is followed by the articles written by the recipients that give a personal account on the discovery process. While there is no guarantee that one will succeed by following their recipe, but there is always a lesson to learn from these good scientists. In particular, how they persisted and determined to look for an answer over many years.

Enjoy!
Fai
—

  1. Goldstein JL. How to win a Lasker? Take a close look at Bathers and Bulls. Nat Med. 2010 Oct;16(10):1091-6. PubMed PMID: 20930751.
  2. Coleman DL. A historical perspective on leptin. Nat Med. 2010Oct;16(10):1097-9. PubMed PMID: 20930752.
  3. Friedman JM. A tale of two hormones. Nat Med. 2010 Oct;16(10):1100-6. PubMedPMID: 20930753.
  4. Ferrara N. Vascular endothelial growth factor and age-related maculardegeneration: from basic science to therapy. Nat Med. 2010 Oct;16(10):1107-11.PubMed PMID: 20930754.
  5. Weatherall D. Thalassemia: the long road from the bedside through thelaboratory to the community. Nat Med. 2010 Oct;16(10):1112-5. PubMed PMID:20930755.
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2010-10-09 New articles we read this week

Saturday, October 9, 2010

Behaviour

  1. Li L. Zebrafish mutants: behavioral genetic studies of visual system defects. Dev Dyn. 2001 Aug;221(4):365-72. Review. PubMed PMID: 11500973.
  2. Orger MB, Gahtan E, Muto A, Page-McCaw P, Smear MC, Baier H. Behavioral screening assays in zebrafish. Methods Cell Biol. 2004;77:53-68. PubMed PMID: 15602905.

Cancer

  1. Feitsma H, Cuppen E. Zebrafish as a cancer model. Mol Cancer Res. 2008 May;6(5):685-94. Review. PubMed PMID: 18505914.

Gene expression

  1. Ohlsson R. Gene expression: The coherent Mediator. Nature. 2010 Sep 23;467(7314):406-7. PubMed PMID: 20864988.

Patterning

  1. Kondo S, Miura T. Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation. Science. 2010 Sep 24; 329; 1616-1620.

Evolution

  1. Burke MK, Dunham JP, Shahrestani P, Thornton KR, Rose MR, Long AD. Genome-wide analysis of a long-term evolution experiment with Drosophila. Nature. 2010 Sep 30;467(7315):587-90. Epub 2010 Sep 15. PubMed PMID: 20844486.

Medicine

  1. Cooke M. Science for Physicians. Science. 2010 Sep 24; 329; 1573.

Gene regulatory network & Systems biology

  1. Acar M, et al., A General Mechanism for Network-Dosage Compensation in Gene Circuits. Science. 2010 Sep 24; 329; 1656-1660.
  2. Young NM, Chong HJ, Hu D, Hallgrímsson B, Marcucio RS. Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape. Development. 2010 Oct;137(20):3405-9. Epub 2010 Sep 8. PubMed PMID: 20826528.
  3. Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G. A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17047-52. Epub 2010 Sep 13. PubMed PMID: 20837528.
  4. Bandyopadhyay et al., A human MAP kinase interactome. Nat. Method. 2010; 7:801-805.
  5. Neems D, Kosak ST. Turning down the volume on transcriptional noise. Nat Cell Biol. 2010 Oct;12(10):929-31. PubMed PMID: 20885421.
  6. Giacomantonio CE, Goodhill GJ. A Boolean model of the gene regulatory network underlying Mammalian cortical area development. PLoS Comput Biol. 2010 Sep 16;6(9). pii: e1000936. PubMed PMID: 20862356; PubMed Central PMCID: PMC2940723.
  7. Stormo GD, Zhao Y. Determining the specificity of protein-DNA interactions. Nat Rev Genet. 2010 Sep 28. [Epub ahead of print] PubMed PMID: 20877328.
  8. Alon U. Network motifs: theory and experimental approaches. Nat Rev Genet. 2007 Jun;8(6):450-61. Review. PubMed PMID: 17510665.

Retina

  1. Allison WT, Barthel LK, Skebo KM, Takechi M, Kawamura S, Raymond PA. Ontogeny of cone photoreceptor mosaics in zebrafish. J Comp Neurol. 2010 Oct 15;518(20):4182-95. PubMed PMID: 20878782.

Delta-Notch signal transduction

  1. Matsuda M, Chitnis AB. Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish. Development. 2010 Oct;137(20):3477-87. PubMed PMID: 20876657.
  2. Milán M, Cohen SM.  Notch signaling: filopodia dynamics confer robustness. Curr Biol. 2010 Sep 28;20(18):R802-4. PMID: 20869605 [PubMed – in process]
  3. Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I. Notch and Wnt signaling mediated rod photoreceptor regeneration by Müller cells in adult mammalian retina. PLoS One. 2010 Aug 26;5(8):e12425. PubMed PMID: 20865053; PubMed Central PMCID: PMC2928741.

Research funding

  1. Powell K. Research funding: Making the cut. Nature. 2010 Sep 23;467(7314):383-5. PubMed PMID: 20864969.

Research ethics

  1. Cyranoski D. Brawl in Beijing. Nature. 2010 Sep 30;467(7315):511. PubMed PMID: 20881985.
  2. Maher B. Research integrity: Sabotage! Nature. 2010 Sep 30;467(7315):516-8. PubMed PMID: 20881988.
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The Nobel Prize in Chemistry 2010

Thursday, October 7, 2010

The Nobel Prize in Chemistry 2010 was awarded to Richard F. Heck, Ei-ichi Negishi, Akira Suzuki “for palladium-catalyzed cross couplings in organic synthesis”. And Ei-ichi Negishi is in the Department of Chemistry at our institute, i.e Purdue!

Richard F. Heck. Photo: University of Delaware, USA

Ei-ichi Negishi. Photo: Purdue University, USA

Akira Suzuki. Photo: Hokkaido University, Japan

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