Leung Lab Blog

Delta-Notch

1. Cohen M, Georgiou M, Stevenson NL, Miodownik M, Baum B. Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell. 2010 Jul 20;19(1):78-89. PubMed PMID: 20643352.

Medicine and ethics

1. Yurkiewicz S.  The Prospects for Personalized Medicine. Hastings Cent Rep. 2010; 40:14-16.
2. Fleck LM. Personalized Medicine’s Ragged Edge. 2010; 40:16-18.
3. Gilbert S. Personalized Cancer Care in an Age of Anxiety. 2010; 40: 18-21.
4. Tillinghast GW. Microarrays in the clinic. Nat Biotechnol. 2010.Aug;28(8):810-2. PubMed PMID: 20697405.
5. Shi L, MAQC Consortium. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based  predictive models. Nat Biotechnol. 2010 Aug;28(8):827-38. Epub 2010 Jul 30. PubMed PMID: 20676074.

Systems biology

1. Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW. Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol. 2010 Oct 5;6:417. PubMed PMID: 20924352.
2. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. A fast, robust and tunable synthetic gene oscillator. Nature. 2008 Nov 27;456(7221):516-9. Epub 2008 Oct 29. PubMed PMID: 18971928.
3. Tigges M, Marquez-Lago TT, Stelling J, Fussenegger M. A tunable synthetic mammalian oscillator. Nature. 2009 Jan 15;457(7227):309-12. PubMed PMID: 19148099.
4. Cağatay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM. Architecture-dependent noise discriminates functionally analogous differentiation circuits. Cell. 2009 Oct 30;139(3):512-22. Epub 2009 Oct 22. PubMed PMID:19853288.
5. Bollenbach T, Kishony R. Quiet gene circuit more fragile than its noisy peer. Cell. 2009 Oct 30;139(3):460-1. PubMed PMID: 19879833.
6. Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE Jr. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 4;321(5885):126-9. PubMed PMID: 18599789; PubMed Central PMCID: PMC2728800.
7. Novák B, Tyson JJ. Design principles of biochemical oscillators. Nat Rev Mol Cell Biol. 2008 Dec;9(12):981-91. Epub 2008 Oct 30. Review. PubMed PMID: 18971947; PubMed Central PMCID: PMC2796343.

Imaging

1. Swoger J, Muzzopappa M, López-Schier H, Sharpe J. 4D retrospective lineage tracing using SPIM for zebrafish organogenesis studies. J Biophotonics. 2010 Oct 5. [Epub ahead of print] PubMed PMID: 20925108.

Zebrafish

1. Kim J, Wu Q, Zhang Y, Wiens KM, Huang Y, Rubin N, Shimada H, Handin RI, Chao MY, Tuan TL, Starnes VA, Lien CL. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17206-10. Epub 2010 Sep 21. PubMed PMID: 20858732.
2. Dlugos CA, Brown SJ, Rabin RA. Gender differences in ethanol-induced behavioral sensitivity in zebrafish. Alcohol. 2010 Sep 28. [Epub ahead of print]PubMed PMID: 20880661.

Development

1. Fujimoto T, Nishimura T, Goto-Kazeto R, Kawakami Y, Yamaha E, Arai K. Sexual dimorphism of gonadal structure and gene expression in germ cell-deficient loach, a teleost fish. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17211-6. Epub 2010 Sep 20. PubMed PMID: 20855617.

Stem cells

1. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL.Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. N Engl J Med. 2010 Jul 21. [Epub ahead of print] PubMed PMID: 20660394.

Vision

1. Demb JB, Brainard DH. Vision: Neurons show their true colours. Nature. 2010 Oct 7;467(7316):670-1. PubMed PMID: 20930837.
2. Field GD, Gauthier JL, Sher A, Greschner M, Machado TA, Jepson LH, Shlens J, Gunning DE, Mathieson K, Dabrowski W, Paninski L, Litke AM, Chichilnisky EJ.Functional connectivity in the retina at the resolution of photoreceptors. Nature. 2010 Oct 7;467(7316):673-7. PubMed PMID: 20930838; PubMed Central PMCID: PMC2953734.
3. Satoh AK, Xia H, Yan L, Liu CH, Hardie RC, Ready DF. Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors. Neuron. 2010 Sep 23;67(6):997-1008. PubMed PMID: 20869596; PubMed Central PMCID: PMC2946946.

General

1. Ørom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, Lai F, Zytnicki M, Notredame C, Huang Q, Guigo R, Shiekhattar R. Long noncoding RNAs with enhancer-like function in human cells. Cell. 2010 Oct 1;143(1):46-58. PubMed PMID: 20887892.
2. Collins F. Scientists need a shorter path to research freedom. Nature. 2010 Oct 7;467(7316):635. PubMed PMID: 20930798.
3. Ledford H. Garage biotech: Life hackers. Nature. 2010 Oct 7;467(7316):650-2. PubMed PMID: 20930820.