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Generation of Chimeric Monkey

Today there is an article published in CELL about the generation of chimeric monkey. Unlike the traditional way for generation of chimeric mouse for making transgenic animal that can utilize pluripotent stem cells or inner cell mass, the process in primates requires the usage of totipotent cells at a much earlier stage – 4-cell stage. The authors could aggregate these early embryos and generate chimera. See a simple and good news coverage from the BBC for further discussions of the importance.

Adopted from the journal website


  1. Tachibana M, Sparman M, Ramsey C, Ma H, Lee HS, Penedo MC, Mitalipov S. Generation of Chimeric Rhesus Monkeys. Cell. 2012 Jan 4. [Epub ahead of print] PubMed PMID: 22225614.
    • Commentary: Trounson A, Grieshammer U. Chimeric Primates: Embryonic Stem Cells Need Not Apply. Cell. 2012 Jan 4. [Epub ahead of print] PubMed PMID: 22225613.