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2016-01-25 new articles we read this week

Eye diseases

  1. Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, Burdon KP, Aschard H, Chasman DI, Igo RP Jr, Hysi PG, Glastonbury CA, Ashley-Koch A, Brilliant M, Brown AA, Budenz DL, Buil A, Cheng CY, Choi H, Christen WG, Curhan G, De Vivo I, Fingert JH, Foster PJ, Fuchs C, Gaasterland D, Gaasterland T, Hewitt AW, Hu F, Hunter DJ, Khawaja AP, Lee RK, Li Z, Lichter PR, Mackey DA, McGuffin P, Mitchell P, Moroi SE, Perera SA, Pepper KW, Qi Q, Realini T, Richards JE, Ridker PM, Rimm E, Ritch R, Ritchie M, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Tamimi RM, Topouzis F, Viswanathan AC, Verma SS, Vollrath D, Wang JJ, Weisschuh N, Wissinger B, Wollstein G, Wong TY, Yaspan BL, Zack DJ, Zhang K, Study EE; ANZRAG Consortium, Weinreb RN, Pericak-Vance MA, Small K, Hammond CJ, Aung T, Liu Y, Vithana EN, MacGregor S, Craig JE, Kraft P, Howell G, Hauser MA, Pasquale LR, Haines JL, Wiggs JL. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet. 2016 Jan 11. doi: 10.1038/ng.3482. [Epub ahead of print] PubMed PMID: 26752265.


  1. Lacomme M, Tarchini B, Boudreau-Pinsonneault C, Monat C, Cayouette M. The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina. Development. 2016 Jan 11. pii: dev.129783. [Epub ahead of print] PubMed PMID: 26755700.

Genome Editing

  1. Hendriks WT, Warren CR, Cowan CA. Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions. Cell Stem Cell. 2016 Jan 7;18(1):53-65. doi: 10.1016/j.stem.2015.12.002. Review. PubMed PMID: 26748756; PubMed Central PMCID: PMC4709030.
  2. Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat Biotechnol. 2016 Jan 11. doi: 10.1038/nbt.3450. [Epub ahead of print] PubMed PMID: 26751173.
  3. Amitai G, Sorek R. CRISPR-Cas adaptation: insights into the mechanism of action. Nat Rev Microbiol. 2016 Jan 11. doi: 10.1038/nrmicro.2015.14. [Epub ahead of print] PubMed PMID: 26751509.
  4. Lander ES. The Heroes of CRISPR. Cell. 2016 Jan 14;164(1-2):18-28. doi: 10.1016/j.cell.2015.12.041. Review. PubMed PMID: 26771483.
  5. Wright AV, Nuñez JK, Doudna JA. Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering. Cell. 2016 Jan 14;164(1-2):29-44. doi: 10.1016/j.cell.2015.12.035. Review. PubMed PMID: 26771484.
  6. Araki M, Ishii T. Providing Appropriate Risk Information on Genome Editing for Patients. Trends Biotechnol. 2016 Feb;34(2):86-90. doi: 10.1016/j.tibtech.2015.12.002. PubMed PMID: 26802361.
  7. Ledford H. Bitter fight over CRISPR patent heats up. Nature. 2016 Jan 21;529(7586):265. doi: 10.1038/nature.2015.17961. PubMed PMID: 26791698.


  1. Sugimura K, Lenne PF, Graner F. Measuring forces and stresses in situ in living tissues. Development. 2016 Jan 15;143(2):186-96. doi: 10.1242/dev.119776. Review. PubMed PMID: 26786209.
  2. Cembrowski MS, Bachman JL, Wang L, Sugino K, Shields BC, Spruston N. Spatial Gene-Expression Gradients Underlie Prominent Heterogeneity of CA1 Pyramidal Neurons. Neuron. 2016 Jan 13. pii: S0896-6273(15)01086-7. doi: 10.1016/j.neuron.2015.12.013. [Epub ahead of print] PubMed PMID: 26777276.


  1. Snyder MW, Kircher M, Hill AJ, Daza RM, Shendure J. Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin. Cell. 2016 Jan 14;164(1-2):57-68. doi: 10.1016/j.cell.2015.11.050. PubMed PMID: 26771485; PubMed Central PMCID: PMC4715266.
  2. Khurana E, Fu Y, Chakravarty D, Demichelis F, Rubin MA, Gerstein M. Role of non-coding sequence variants in cancer. Nat Rev Genet. 2016 Jan 19. doi: 10.1038/nrg.2015.17. [Epub ahead of print] PubMed PMID: 26781813.
  3. Andrews KR, Good JM, Miller MR, Luikart G, Hohenlohe PA. Harnessing the power of RADseq for ecological and evolutionary genomics. Nat Rev Genet. 2016 Jan 5. doi: 10.1038/nrg.2015.28. [Epub ahead of print] PubMed PMID: 26729255.


  1. Indjeian VB, Kingman GA, Jones FC, Guenther CA, Grimwood J, Schmutz J, Myers RM, Kingsley DM. Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins. Cell. 2016 Jan 14;164(1-2):45-56. doi: 10.1016/j.cell.2015.12.007. Epub 2016 Jan 7. PubMed PMID: 26774823.

Science career

My adviser’s best advice


  1. Yang W, Miller JK, Carrillo-Reid L, Pnevmatikakis E, Paninski L, Yuste R, Peterka DS. Simultaneous Multi-plane Imaging of Neural Circuits. Neuron. 2016 Jan 5. pii: S0896-6273(15)01085-5. doi: 10.1016/j.neuron.2015.12.012. [Epub ahead of print] PubMed PMID: 26774159.
  2. Silbereis JC, Pochareddy S, Zhu Y, Li M, Sestan N. The Cellular and Molecular Landscapes of the Developing Human Central Nervous System. Neuron. 2016 Jan 20;89(2):248-68. doi: 10.1016/j.neuron.2015.12.008. Review. PubMed PMID: 26796689.