Leung Lab Blog

Genomics

1. Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR. Gene essentiality and synthetic lethality in haploid human cells. Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PubMed PMID: 26472760.
2. Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science. 2015 Nov 27;350(6264):1096-101. doi: 10.1126/science.aac7041. Epub 2015 Oct 15. PubMed PMID: 26472758; PubMed Central PMCID: PMC4662922.
   • Commentary: Boone C, Andrews BJ. HUMAN GENOME. The indispensable genome. Science. 2015 Nov 27;350(6264):1028-9. doi: 10.1126/science.aad7925. PubMed PMID: 26612934.
3. Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. 2015 Nov 25. pii: S0092-8674(15)01495-6. doi: 10.1016/j.cell.2015.11.015. [Epub ahead of print] PubMed PMID: 26627737.

Neuroscience

1. Barker AJ, Baier H. Sensorimotor Decision Making in the Zebrafish Tectum. Curr Biol. 2015 Nov 2;25(21):2804-14. doi: 10.1016/j.cub.2015.09.055. Epub 2015 Oct 22. PubMed PMID: 26592341.

Retina

1. Lahne M, Li J, Marton RM, Hyde DR. Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina. J Neurosci. 2015 Nov 25;35(47):15612-34. doi: 10.1523/JNEUROSCI.5005-14.2015. PubMed PMID: 26609156.
2. Wilson SG, Wen W, Kastoori LP, Morris AC. Tracking the fate of her4 expressing cells in the regenerating retina using her4:Kaede zebrafish. Exp Eye Res. 2015 Nov 23. pii: S0014-4835(15)30061-0. doi: 10.1016/j.exer.2015.11.002. [Epub ahead of print] PubMed PMID: 26616101.
3. Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, Dyer MA. Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Development. 2015 Dec 1;142(23):4092-106. doi: 10.1242/dev.124800. PubMed PMID: 26628093.

Genome editing

1. van der Oost J, Brouns SJ. CRISPR sabotage. Genome Biol. 2015 Nov 9;16(1):248. doi: 10.1186/s13059-015-0820-0. PubMed PMID: 26553202; PubMed Central PMCID: PMC4638106.
2. Kühn R, Chu VT. Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9. Genome Biol. 2015 Nov 10;16(1):244. doi: 10.1186/s13059-015-0810-2. PubMed PMID: 26553112; PubMed Central PMCID: PMC4640370.
3. Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biol. 2015 Nov 10;16(1):231. doi: 10.1186/s13059-015-0791-1. PubMed PMID: 26553065; PubMed Central PMCID: PMC4640169.
4. Graham DB, Root DE. Resources for the design of CRISPR gene editing experiments. Genome Biol. 2015 Nov 27;16(1):260. doi: 10.1186/s13059-015-0823-x. PubMed PMID: 26612492; PubMed Central PMCID: PMC4661947.
5. Friedland AE, Baral R, Singhal P, Loveluck K, Shen S, Sanchez M, Marco E, Gotta GM, Maeder ML, Kennedy EM, Kornepati AV, Sousa A, Collins MA, Jayaram H, Cullen BR, Bumcrot D. Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications. Genome Biol. 2015 Nov 24;16(1):257. doi: 10.1186/s13059-015-0817-8. PubMed PMID: 26596280; PubMed Central PMCID: PMC4657203.

Development

1. Briscoe J, Small S. Morphogen rules: design principles of gradient-mediated embryo patterning. Development. 2015 Dec 1;142(23):3996-4009. doi: 10.1242/dev.129452. Review. PubMed PMID: 26628090.