Leung Lab Blog

Systems biology

1. Levo M, Segal E. In pursuit of design principles of regulatory sequences. Nat Rev Genet. 2014 Jul;15(7):453-68. doi: 10.1038/nrg3684. Epub 2014 Jun 10. PubMed PMID: 24913666.
2. Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014 Jun 20;344(6190):1396-401. doi: 10.1126/science.1254257. Epub 2014 Jun 12. PubMed PMID: 24925914.

Stem cells

1. Cattaneo E, Corbellini G. Stem cells: taking a stand against pseudoscience. Nature. 2014 Jun 19;509(7505):333-5. PubMed PMID: 24955466.
2. Bertolotti E, Neri A, Camparini M, Macaluso C, Marigo V. Stem cells as source for retinal pigment epithelium transplantation. Prog Retin Eye Res. 2014 Jun 13. pii: S1350-9462(14)00037-8. doi: 10.1016/j.preteyeres.2014.06.002. [Epub ahead of print] Review. PubMed PMID: 24933042.
3. Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5?32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014 Jun 9. pii: 201407473. [Epub ahead of print] PubMed PMID: 24927590.
4. Park CY, Kim J, Kweon J, Son JS, Lee JS, Yoo JE, Cho SR, Kim JH, Kim JS, Kim DW. Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9253-8. doi: 10.1073/pnas.1323941111. Epub 2014 Jun 9. PubMed PMID: 24927536.

Neuroscience

1. Rose N. The human brain project: social and ethical challenges. Neuron. 2014 Jun 18;82(6):1212-5. doi: 10.1016/j.neuron.2014.06.001. PubMed PMID: 24945767.
2. Cohen MA, Konkle T, Rhee JY, Nakayama K, Alvarez GA. Processing multiple visual objects is limited by overlap in neural channels. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8955-60. doi: 10.1073/pnas.1317860111. Epub 2014 Jun 2. PubMed PMID: 24889618.
3. Prevedel R, Yoon YG, Hoffmann M, Pak N, Wetzstein G, Kato S, Schrödel T, Raskar R, Zimmer M, Boyden ES, Vaziri A. Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy. Nat Methods. 2014 Jul;11(7):727-30. doi: 10.1038/nmeth.2964. Epub 2014 May 18. PubMed PMID: 24836920.

Neurobehaviour

1. Pérez-Escudero A, Vicente-Page J, Hinz RC, Arganda S, de Polavieja GG. idTracker: tracking individuals in a group by automatic identification of unmarked animals. Nat Methods. 2014 Jul;11(7):743-8. doi: 10.1038/nmeth.2994. Epub 2014 Jun 1. PubMed PMID: 24880877.

Psychology

1. Jung K, Shavitt S, Viswanathan M, Hilbe JM. Female hurricanes are deadlier than male hurricanes. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8782-7. doi: 10.1073/pnas.1402786111. Epub 2014 Jun 2. PubMed PMID: 24889620.

Retinal Development

1. Laranjeiro R, Whitmore D. Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation. Development. 2014 Jun 12. pii: dev.104380. [Epub ahead of print] PubMed PMID: 24924194.

Eye diseases

1. Huber-Reggi SP, Mueller KP, Straumann D, Huang MY, Neuhauss SC. Individual Larvae of the Zebrafish Mutant belladonna Display Multiple Infantile Nystagmus-Like Waveforms that Are Influenced by Viewing Conditions. Invest Ophthalmol Vis Sci. 2014 May 27;55(6):3971-8. doi: 10.1167/iovs.13-13576. PubMed PMID: 24867578.

Zebrafish

1. Law SH, Sargent TD. The Serine-Threonine Protein Kinase PAK4 Is Dispensable in Zebrafish: Identification of a Morpholino-Generated Pseudophenotype. PLoS One. 2014 Jun 19;9(6):e100268. doi: 10.1371/journal.pone.0100268. eCollection 2014. PubMed PMID: 24945275.

Genome editing/medicine

1. Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5?32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014 Jun 9. pii: 201407473. [Epub ahead of print] PubMed PMID: 24927590.
2. Park CY, Kim J, Kweon J, Son JS, Lee JS, Yoo JE, Cho SR, Kim JH, Kim JS, Kim DW. Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9253-8. doi: 10.1073/pnas.1323941111. Epub 2014 Jun 9. PubMed PMID: 24927536.
3. Kiani S, Beal J, Ebrahimkhani MR, Huh J, Hall RN, Xie Z, Li Y, Weiss R. CRISPR
   transcriptional repression devices and layered circuits in mammalian cells. Nat
   Methods. 2014 Jul;11(7):723-6. doi: 10.1038/nmeth.2969. Epub 2014 May 5. PubMed
   PMID: 24797424.
4. Nissim L, Perli SD, Fridkin A, Perez-Pinera P, Lu TK. Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells. Mol Cell. 2014 May 22;54(4):698-710. doi: 10.1016/j.molcel.2014.04.022. Epub 2014 May 15. PubMed PMID: 24837679.

Drug Discovery

1. Wang YN, Hou YY, Sun MZ, Zhang CY, Bai G, Zhao X, Feng XZ. Behavioural screening of zebrafish using neuroactive traditional Chinese medicine prescriptions and biological targets. Sci Rep. 2014 Jun 16;4:5311. doi: 10.1038/srep05311. PubMed PMID: 24931174; PubMed Central PMCID: PMC4058885.

Science Career

1. Casadevall A, Fang FC. Causes for the persistence of impact factor mania. MBio. 2014 Mar 18;5(2):e00064-14. doi: 10.1128/mBio.00064-14. PubMed PMID: 24643863; PubMed Central PMCID: PMC3967521.

Development

1. Nicolas M, Hassan BA. Amyloid precursor protein and neural development. Development. 2014 Jul;141(13):2543-8. doi: 10.1242/dev.108712. PubMed PMID: 24961795.
2. Deneris ES, Hobert O. Maintenance of postmitotic neuronal cell identity. Nat Neurosci. 2014 Jul;17(7):899-907. doi: 10.1038/nn.3731. Epub 2014 Jun 15. PubMed PMID: 24929660.

Methods

1. Hughes AJ, Spelke DP, Xu Z, Kang CC, Schaffer DV, Herr AE. Single-cell western blotting. Nat Methods. 2014 Jul;11(7):749-55. doi: 10.1038/nmeth.2992. Epub 2014  Jun 1. PubMed PMID: 24880876.