Leung Lab Blog

Systems biology, gene regulatory network & development

1. Huang S, Eichler G, Bar-Yam Y, Ingber DE. Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett. 2005 Apr 1;94(12):128701. Epub 2005 Apr 1. PubMed PMID: 15903968.
2. Chang HH, Hemberg M, Barahona M, Ingber DE, Huang S. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature. 2008 May 22;453(7194):544-7. PubMed PMID: 18497826.
3. Bar-Yam Y, Harmon D, de Bivort B. Systems biology. Attractors and democratic dynamics. Science. 2009 Feb 20;323(5917):1016-7. PubMed PMID: 19229023.
4. Brock A, Chang H, Huang S. Non-genetic heterogeneity–a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet. 2009 May;10(5):336-42. PubMed PMID: 19337290.

Delta-Notch & cancer

1. Pancewicz J, Taylor JM, Datta A, Baydoun HH, Waldmann TA, Hermine O, Nicot C. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16619-24. Epub 2010 Sep 7. PubMed PMID: 20823234.
2. Schouwey K, Aydin IT, Radtke F, Beermann F. RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice. Oncogene. 2010 Sep 20. [Epub ahead of print] PubMed PMID: 20856205.

Neuroscience

1. Portales-Casamar E, Swanson DJ, Liu L, Leeuw CN, Banks KG, Ho Sui SJ, FultonDL, Ali J, Amirabbasi M, Arenillas DJ, Babyak N, Black SF, Bonaguro RJ, Brauer E, Candido TR, Castellarin M, Chen J, Chen Y, Cheng JC, Chopra V, Docking TR, Dreolini L, D’Souza CA, Flynn EK, Glenn R, Hatakka K, Hearty TG, Imanian B, Jiang S, Khorasan-Zadeh S, Komljenovic I, Laprise S, Liao NY, Lim JS, Lithwick S, Liu F, Liu J, Lu M, McConechy M, McLeod AJ, Milisavljevic M, Mis J, O’Connor K, Palma B, Palmquist DL, Schmouth JF, Swanson MI, Tam B, Ticoll A, Turner JL, Varhol R, Vermeulen J, Watkins RF, Wilson G, Wong BK, Wong SH, Wong TY, Yang GS, Ypsilanti AR, Jones SJ, Holt RA, Goldowitz D, Wasserman WW, Simpson EM. A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16589-94. Epub 2010 Aug 31. PubMed PMID: 20807748.

Genomics

1. Listgarten J, Kadie C, Schadt EE, Heckerman D. Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16465-70. Epub 2010 Sep 1. PubMed PMID: 20810919.
2. Hohm T, Zitzler E. A hierarchical approach to model parameter optimization for developmental systems. Biosystems. 2010 Sep 21. [Epub ahead of print] PubMed PMID: 20851739.