Leung Lab Blog

Genetics

1. Klein RJ, Xu X, Mukherjee S, Willis J, Hayes J. Successes of Genome-wide Association Studies. Cell. 2010 Aug 6;142(3):350-1. PubMed PMID: 20691890.
2. Wang K, Bucan M, Grant SF, Schellenberg G, Hakonarson H. Strategies for genetic studies of complex diseases. Cell. 2010 Aug 6;142(3):351-3. PubMed PMID: 20691891.
3. McClellan J, King MC. Response: why it is time to sequence. Cell. 2010 Aug 6;142(3):353-5. PubMed PMID: 20691892.
4. Wilkinson LS. Developmental biology. Which parental gene gets the upper hand? Science. 2010 Aug 6;329(5992):636-7. PubMed PMID: 20689006.

Segmentation

1. Masamizu Y, Ohtsuka T, Takashima Y, Nagahara H, Takenaka Y, Yoshikawa K, Okamura H, Kageyama R. Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1313-8. Epub 2006 Jan 23. PubMed PMID: 16432209; PubMed Central PMCID: PMC1345707.
2. Hirata H, Bessho Y, Kokubu H, Masamizu Y, Yamada S, Lewis J, Kageyama R. Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet. 2004 Jul;36(7):750-4. Epub 2004 May 30. PubMed PMID: 15170214.

Delta-Notch

1. Sang L, Coller HA, Roberts JM. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science. 2008 Aug 22;321(5892):1095-100. PubMed PMID: 18719287; PubMed Central PMCID: PMC2721335.
2. Breunig JJ, Silbereis J, Vaccarino FM, Sestan N, Rakic P. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20558-63. Epub 2007 Dec 11. PubMed PMID: 18077357; PubMed Central PMCID: PMC2154470.
3. Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R. Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76. Epub 2006 May 25. PubMed PMID: 16728479.
4. Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K, Kageyama R. Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science. 2002 Oct 25;298(5594):840-3. PubMed PMID: 12399594.

Systems Biology

1. Rusk N. Advent of synthetic life. Nat Methods. 2010 Jul;7(7):487. PubMed PMID: 20603906.
2. Moseley JB, Nurse P. Cell division intersects with cell geometry. Cell. 2010 Jul 23;142(2):184-8. PubMed PMID: 20655459.

Neuroscience

1. Clark DA, de Vries SE, Clandinin TR. Watching the fly brain in action. Nat Methods. 2010 Jul;7(7):505-6. PubMed PMID: 20588268.

Nature Insights Plasticity

1. Yamanaka S, Blau HM. Nuclear reprogramming to a pluripotent state by three approaches. Nature. 2010 Jun 10;465(7299):704-12. Review. PubMed PMID: 20535199; PubMed Central PMCID:PMC2901154.
2. Pera MF, Tam PP. Extrinsic regulation of pluripotent stem cells. Nature. 2010 Jun 10;465(7299):713-20. Review. PubMed PMID: 20535200.
3. Petronis A. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature. 2010 Jun 10;465(7299):721-7. PubMed PMID: 20535201.
4. Dulac C. Brain function and chromatin plasticity. Nature. 2010 Jun
   10;465(7299):728-35. Review. PubMed PMID: 20535202.
5. Spiller DG, Wood CD, Rand DA, White MR. Measurement of single-cell dynamics. Nature. 2010 Jun 10;465(7299):736-45. Review. PubMed PMID: 20535203.