Publications

Purdue era [ 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 ]

Pre-Purdue era [ 2007 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999]

2024

  1. Andrews G, Andrews G, Leung YF, Suter DM. A Robust Paradigm for Studying Regeneration after Traumatic Spinal Cord Injury in Zebrafish. J Neurosci Methods. 2024 Aug 6 [PubMed][Full text][pdf]
  2. Wu X, Chan YS, Xiang B, Zhang W, Luk KM, Cheng SH, Leung YF, Chan RHM. Scalable Neuroanatomical and Behavioral Phenotyping of Radio Frequency Radiation on Young Zebrafish. IEEE Open J Eng Med Biol. 2024 Jun 28 [PubMed][Full text][pdf]

2023

  1. Wang BC and Leung YF. Feature Selection for Multivariate Time-Series Data After Tensor Reduction [version 1; not peer reviewed]. F1000Research 2023, 12:1556 (poster). (doi: 10.7490/f1000research.1119679.1) 

2021

  1. Ganzen L, Ko MJ, Zhang M, Xie R, Chen Y, Zhang LY, James R, Mumm J, van Rijn R, Zhong W, Pang CP, Zhang M, Tsuijikawa M, Leung YF. Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for an Autosomal Dominant form of Retinitis Pigmentosa. Sci Rep. 2021 Jun 1;11(1):11432. [PubMed][Full text][pdf]

2020

  1. Venkatraman P, Mills-Henry I, Padmanabhan KR, Pascuzzi P, Hassan M, Zhang J, Zhang X, Ma P, Pang CP, Dowling JE, Zhang M, Leung YF. Rods contribute to visual behaviour in larval zebrafish. Invest Ophthalmol Vis Sci. 2020;61(12):11. [PubMed][Full text][pdf]
  2. Ganzen L, Ko MJ, Zhang M, Xie R, Chen Y, Zhang LY, James R, Mumm J, van Rijn R, Zhong W, Pang CP, Zhang M, Tsuijikawa M, Leung YF. Drug screening with zebrafish visual behaviour identifies carvedilol as a potential treatment for retinitis pigmentosa. bioRxiv. 2020.07.28.225789 [Full text][pdf]

2019

  1. Coskun E. A Pharmacological Model of TRPA1-Mediated Nociception in Zebrafish for Therapeutic Discovery. Journal of Purdue Undergraduate Research. [Journal page][pdf]
  2. Ko MJ, Ganzen LC, Coskun E, Mukadam AA, Leung YF, van Rijn RM. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep. 2019 Feb 20;9(1):2430. [PubMed][Full Text][pdf]
  3. Xie R, Zhang M, Venkatraman P, Zhang X, Zhang G, Carmer R, Kantola SA, Pang CP, Ma P, Zhang M, Zhong W, Leung YF. Normalization of large-scale behavioural data collected from zebrafish. PLoS One. 2019 Feb 15;14(2):e0212234. [PubMed][Full text][pdf]

2018

  1. Weaver C, Terzi A, Roeder H, Gurol T, Deng Q, Leung YF, Suter DM. nox2/cybb deficiency affects zebrafish retinotectal connectivity. J Neurosci. 2018 Jun 27;38(26):5854-5871.[PubMed][Full text][pdf].
  2. Huang XF, Xiang L, Cheng W, Cheng FF, He KW, Zhang BW, Zheng SS, Han RY, Zheng YH, Xu XT, Yu HY, Zhuang W, Leung YF, Jin ZB. Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract. Exp Mol Med. 2018 Apr 27;50(4):53. [PubMed][Full text][pdf]

2017

  1. Zhang L, Zhang X, Zhang G, Pang CP, Leung YF, Zhang M, Zhong W. Expression profiling of the retina of pde6c, a zebrafish model of retinal degeneration. Sci Data. 2017 Dec 12;4:170182. [PubMed][Full text][pdf][Data in GEO]
  2. Liu Y, Ma P, Cassidy PA, Carmer R, Zhang G, Venkatraman P, Brown SA, Pang CP, Zhong W, Zhang M, Leung YF. Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed Models. Sci Rep. 2017 Jun 7;7(1):2937. [PubMed][Full text][pdf]
  3. Ganzen L, Venkatraman P, Pang CP, Leung YF, Zhang M. Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. Int J Mol Sci. 2017 Jun 2;18(6). pii: E1185. [PubMed][Full text][pdf]

2016

  1. Hensley MR, Chua RFM, Leung YF, Yang JY, Zhang GJ. Molecular evolution of MDM1, a “duplication-resistant” gene in vertebrates. PLOS ONE. 2016 Sep 22;11(9):e0163229. [PubMed][Full text][pdf]
  2. Weaver CJ, Leung YF, Suter DM. Expression dynamics of NADPH oxidases during early zebrafish development. J Comp Neurol. 2016 Jul 1;524(10):2130-41.[PubMed][Full text][pdf]
  3. Hensley M, Cui Z, Chua R, Simpson S, Shammas N, Yang JY, Leung YF, Zhang GJ. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Sci Rep. 2016 Jun 13;6:27816. [PubMed][Full text][pdf]
  4. Zhang L, Xiang L, Liu Y, Venkatraman P, Chong L, Cho J, Bonilla S, Jin ZB, Pang CP, Ko KM, Ma P, Zhang M, Leung YF. A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration. PLoS One. 2016 Mar 1;11(3):e0149663. [PubMed][Full text][pdf]
  5. Gao Y, Zhang G, Jelfs B, Carmer R, Venkatraman P, Ghadami M, Brown SA, Pang CP, Leung YF, Chan RH, Zhang M. Computational classification of different wild-type zebrafish strains based on their variation in light-induced locomotor response. Comput Biol Med. 2016 Feb 1;69:1-9.[PubMed][Full text][pdf]

2015

  1. Liu Y, Carmer R, Zhang G, Venkatraman P, Brown SA, Pang CP, Zhang M, Ma P, Leung YF. Statistical analysis of zebrafish locomotor response. PLOS ONE. 2015; 10(10): e0139521. [PubMed][Full text][pdf]
  2. Bishop B, Ho KK, Tyler K, Smith A, Bonilla S, Leung YF, Ogas J. The chromatin  remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochim Biophys Acta. 2015 Jun 17;1849(8):1040-1050. [PubMed][Full text][pdf]

2014

  1. Gao Y, Chan RHM, Chow TWS, Zhang L, Bonilla S, Pang CP, Zhang M, Leung YF. A high-throughput zebrafish screening method for visual mutants by light-induced locomotor response. IEEE/ACM Trans Comput Biol Bioinform. 2014 Jul-Aug;11:693-701 [PubMed][Full text][pdf]
  2. Zhang L, Bonilla S, Zhang Y, Leung YF. p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1. Dev Dyn. 2014 Feb;243(2):315-23. [PubMed][Full text][pdf]
  3. Zhang L, Ma P, Collery R, Trowbridge S, Zhang M, Zhong W, Leung YF. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. Mol Vis. 2014 Jan 6;20:56-72. [PubMed][Full text][pdf]

2013

  1. Zhang Y, Bonilla S, Chong L, Leung YF. Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene Expr Patterns. 2013 Jun-Jul;13:177-82. [PubMed][Full text][pdf]
  2. Zhang L, Cho J, Ptak D, Leung YF. The role of egr1 in early zebrafish retinogenesis. PLOS ONE. 2013; 8(2): e56108. [PubMed][Full text][pdf]
  3. Li Z, Zhang L, Leung YF. Use of the zebrafish model to study refractive error. Expert Rev Ophthalmol. 2013; 8(1):1-3. (Invited Editorial Article) [Full text][pdf]

2012

  1. Zhang L, Chong L, Cho J, Liao PC, Shen F, Leung YF. Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery? Asia Pac J Ophthalmol (Phila). 2012 Nov-Dec;1(6):374-83. (Invited Review) [PubMed][Full text][pdf][Final peer-reviewed manuscript]
    • Featured in the American Academy of Ophthalmology Academy Express - Asia-Pacific Edition, December 15, 2012
    • Editor's Picks, Asia-Pac J Ophthalmol.
  2. Li Z, Ptak D, Zhang L, Walls EK, Zhong W, Leung YF. Phenylthiourea specifically reduces zebrafish eye size. PLoS ONE. 2012;7(6):e40132. [PubMed][Full text][pdf]
  3. Zhang Y, Yang Y, Trujillo CM, Zhong W, Leung YF. The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper development of both inner and outer nuclear layers and formation of retinal lamination. PLoS ONE. 2012;7(4): e36145. [PubMed][Full text][pdf]
  4. Hensley MR, Hassenplug E, McPhail R, Leung YF. ZeBase: An open-source relational database for zebrafish laboratories. Zebrafish. 2012;9(1):44-9. [PubMed][pdf][link to website]

2011

  1. Hensley MR, Emran F, Bonilla S, Zhang L, Zhong W, Grosu P, Dowling JE, Leung YF. Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas. BMC Dev Biol. 2011 Jul 14;11(1):45. [PubMed][Full text][pdf]

2010

  1. Zhang L, Leung YF. Microdissection of Zebrafish Embryonic Eye Tissues. J. Vis. Exp. 2010; 40. pii: 2028. [PubMed][pdf][Flash Video]
  2. Hensley MR, Leung YF. A Convenient Dry Feed for Raising Zebrafish Larvae. Zebrafish. 2010; 7:219-31. [PubMed][pdf][Supp. Materials]

2008

  1. Leung, Y.F., Ma, P., Link, B.A., Dowling, J.E. 2008. Factorial microarray analysis of zebrafish retinal development. Proc Natl Acad Sci U S A. 105. 35. 12909-12914. [PubMed][pdf][Supplementary Information][Data in GEO]

2007

  1. Leung, Y. F., Ma, P., Dowling, J. E. 2007. Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Invest Ophthalmol Vis Sci. 48. 2. 881-890. [PubMed][pdf][Supplementary Information]

2005

  1. Leung, Y. F., Dowling, J. E. 2005. Gene expression profiling of zebrafish embryonic retina. Zebrafish. 2. 4. 269-283. [PubMed][pdf][Data in GEO]

2004

  1. Fan, B. J., Leung, Y. F., Pang, C. P., Baum, L., Tam, O. S., Wang, N., Lam, S. C. 2004. Single nucleotide polymorphisms of the myocilin gene in primary open-angle glaucoma patients. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21. 1. 70-73. [PubMed]
  2. Fan, B. J., Leung, Y. F., Pang, C. P., Fan, D. S., Wang, D. Y., Tong, W. C., Tam, P. O., Chua, J. K., Lau, T. C., Lam, D. S. 2004. Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open-angle glaucoma. J Glaucoma. 13. 5. 377-384. [PubMed]
  3. Fan, B. J., Leung, Y. F., Wang, N., Lam, S. C., Liu, Y., Tam, O. S., Pang, C. P. 2004. Genetic and environmental risk factors for primary open-angle glaucoma. Chin Med J (Engl). 117. 5. 706-710. [PubMed][pdf]

2003

  1. Fan BJ, Leung YF. Beginning microarray data analysis for biologists. J Cell Sci. 2003; 116: 1649-1650. [Full text][pdf]
  2. Lam, D. S., Lee, W. S., Leung, Y. F., Tam, P. O., Fan, D. S., Fan, B. J., Pang, C. P. 2003. TGFbeta-induced factor: a candidate gene for high myopia. Invest Ophthalmol Vis Sci. 44. 3. 1012-1015. [PubMed][pdf]
  3. Lam, D. S., Tam, P. O., Fan, D. S., Baum, L., Leung, Y. F., Pang, C. P. 2003. Familial high myopia linkage to chromosome 18p. Ophthalmologica. 217. 2. 115-118. [PubMed]
  4. Leung YF. The Essence of Interdisciplinary Research--Mindset Matters. Science. 2003. [Full text]
  5. Leung, Y. F., Cavalieri, D. 2003. Fundamentals of cDNA microarray data analysis. Trends Genet. 19. 11. 649-659. [PubMed][Full text][pdf]
  6. Leung, Y. F., Fan, B. J., Lam, D. S., Lee, W. S., Tam, P. O., Chua, J. K., Tham, C. C., Lai, J. S., Fan, D. S., Pang, C. P. 2003. Different optineurin mutation pattern in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 44. 9. 3880-3884. [PubMed][pdf]
  7. Leung, Y. F., Tam, P. O., Lee, W. S., Lam, D. S., Yam, H. F., Fan, B. J., Tham, C. C., Chua, J. K., Pang, C. P. 2003. The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells. Mol Vis. 9. 425-439. [PubMed][pdf]

2002

  1. Leung YF, Lam DS, Pang CP. Microarray software review. In: A practical approach to microarray data analysis. D.P. Berrar, W. Dubitzky and M. Granzow, (Eds.), Kluwer academic, 2002. [Full text]
  2. Leung, Y. F. 2002. Unravelling the mystery of microarray data analysis. Trends Biotechnol. 20. 9. 366-368. [PubMed]
  3. Leung YF. 2002. Microarray data analysis for dummies ... and experts too? Trends Biochem Sci. 2002; 27:433-434. [Full text][pdf]
  4. Leung, Y. F., Pang, C. P. 2002. EYE on bioinformatics: dissecting complex disease traits in silico. Appl Bioinformatics. 1. 2. 69-80. [PubMed]
  5. Pang, C. P., Leung, Y. F., Fan, B., Baum, L., Tong, W. C., Lee, W. S., Chua, J. K., Fan, D. S., Liu, Y., Lam, D. S. 2002. TIGR/MYOC gene sequence alterations in individuals with and without primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 43. 10. 3231-3235. [PubMed][pdf]

2001

  1. Leung YF, Pang CP, Browne K.  Guide to microarray hardware - a researcher perspective. Lab-on-a-chip.com 2001 [Full text][table of array scanner][table of manual scanner][table of automatic arrayers]
  2. Leung, Y. F., Lam, D. S., Pang, C. P. 2001. When drugs development meets genomics. Pharmacogenomics J. 1. 4. 237-238. [PubMed]
  3. Leung, Y. F., Lam, D. S., Pang, C. P. 2001. In silico biology: observation, modeling, hypothesis and verification. Trends Genet. 17. 11. 622-623. [PubMed]
  4. Leung, Y. F., Lam, D. S., Pang, C. P. 2001. The miracle of microarray data analysis. Genome Biol. 2. 9. REPORTS4021. [PubMed][pdf]
  5. Leung, Y. F., Pang, C. P. 2001. Trends in proteomics. Trends Biotechnol. 19. 12. 480-482. [PubMed]
  6. Leung, Y. F., Pang, C. P. 2001. All aboard the chip! Trends Biotechnol. 19. 11. 430-431. [PubMed]
  7. Leung, Y. F., Tam, P. O., Tong, W. C., Baum, L., Choy, K. W., Lam, D. S., Pang, C. P. 2001. High-throughput conformation-sensitive gel electrophoresis for discovery of SNPs. Biotechniques. 30. 2. 334-335, 338-340. [PubMed]

2000

  1. Lam, D. S., Leung, Y. F., Chua, J. K., Baum, L., Fan, D. S., Choy, K. W., Pang, C. P. 2000. Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 41. 6. 1386-1391. [PubMed][pdf]
  2. Leung, Y. F., Baum, L., Lam, D. S., Fan, D. S., Chua, J. K., Pang, C. P. 2000. Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. Hum Genet. 107. 4. 404-405. [PubMed]
  3. Leung, Y. F., Tam, P. O., Baum, L., Chan, W. M., Lam, D. S., Pang, C. P. 2000. Cost savings using automated DNA sequencing. Biotechniques. 29. 3. 544. [PubMed]
  4. Leung, Y. F., Tam, P. O., Baum, L., Lam, D. S., Pang, C. C. 2000. TIGR/MYOC proximal promoter GT-repeat polymorphism is not associated with myopia. Hum Mutat. 16. 6. 533. [PubMed]
  5. Pang, C. P., Leung, Y. F., Chua, J. K., Baum, L., Fan, D. S., Lam, D. S. 2000. Novel TIGR sequence alteration Val53Ala. Hum Mutat. 15. 1. 122. [PubMed]

1999

  1. Baum, L., Pang, C. P., Fan, D. S., Poon, P. M., Leung, Y. F., Chua, J. K., Lam, D. S. 1999. Run-on mutation and three novel nonsense mutations identified in the PAX6 gene in patients with aniridia. Hum Mutat. 14. 3. 272-273. [PubMed]