Genomics Li X, Xiong X, Yi C. Epitranscriptome sequencing technologies: decoding RNA modifications. Nat Methods. 2016 Dec 29;14(1):23-31. doi: 10.1038/nmeth.4110. PubMed PMID: 28032622. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, […]
A fundamental but elusive step in the early evolution of life on Earth has been replicated in a laboratory. Researchers synthesized the basic ingredients of RNA, a molecule from which the simplest self-replicating structures are made. Until now, they couldn’t explain how these ingredients might have formed. …. No matter how they combined the ingredients […]
We briefly mentioned the idea of silent mutation in the lab meeting the other day when we discussed how DNA mutations can cause diseases. In general, a polymorphism in the wobble (3rd) position of the DNA codon often would not change the amino acid sequence. However, that doesn’t mean everything would be the same or […]