Synthetic biology
* a very nice review series about the potential of synthetic biology
- Vinson V, Pennisi E. Synthetic biology. The allure of synthetic biology. Introduction. Science. 2011 Sep 2;333(6047):1235. PubMed PMID: 21885767.
- Bohannon J. The life hacker. Science. 2011 Sep 2;333(6047):1236-7. PubMed PMID: 21885768.
- Kean S. A lab of their own. Science. 2011 Sep 2;333(6047):1240-1. PubMed PMID: 21885770.
- Reardon S. Visions of synthetic biology. Science. 2011 Sep 2;333(6047):1242-3. PubMed PMID: 21885771.
- Nandagopal N, Elowitz MB. Synthetic biology: integrated gene circuits. Science. 2011 Sep 2;333(6047):1244-8. Review. PubMed PMID: 21885772.
- Ruder WC, Lu T, Collins JJ. Synthetic biology moving into the clinic. Science. 2011 Sep 2;333(6047):1248-52. Review. PubMed PMID: 21885773.
- Xie Z, Wroblewska L, Prochazka L, Weiss R, Benenson Y. Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science. 2011 Sep 2;333(6047):1307-11. PubMed PMID: 21885784.
- Mondragón-Palomino O, Danino T, Selimkhanov J, Tsimring L, Hasty J. Entrainment of a population of synthetic genetic oscillators. Science. 2011 Sep 2;333(6047):1315-9. PubMed PMID: 21885786.
Epigenetics
- Nabel CS, Kohli RM. Molecular biology. Demystifying DNA demethylation. Science. 2011 Sep 2;333(6047):1229-30. PubMed PMID: 21885763.
Delta-Notch signal transduction
- del Álamo D, Rouault H, Schweisguth F. Mechanism and significance of cis-inhibition in Notch signalling. Curr Biol. 2011 Jan 11;21(1):R40-7. Review. PubMed PMID: 21215938.
- Sprinzak D, Lakhanpal A, Lebon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB. Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature. 2010 May 6;465(7294):86-90. Epub 2010 Apr 25. PubMed PMID: 20418862; PubMed Central PMCID: PMC2886601.
- Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz MB. Mutual inactivation of Notch receptors and ligands facilitates developmental patterning. PLoS Comput Biol. 2011 Jun;7(6):e1002069. Epub 2011 Jun 9. PubMed PMID: 21695234; PubMed Central PMCID: PMC3111533.
- Shaya O, Sprinzak D. From Notch signaling to fine-grained patterning: Modeling meets experiments. Curr Opin Genet Dev. 2011 Aug 19. [Epub ahead of print] PubMed PMID: 21862316.
Genomics
- Gabriel R, Lombardo A, Arens A, Miller JC, Genovese P, Kaeppel C, Nowrouzi A, Bartholomae CC, Wang J, Friedman G, Holmes MC, Gregory PD, Glimm H, Schmidt M, Naldini L, von Kalle C. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol. 2011 Aug 7;29(9):816-23. doi: 10.1038/nbt.1948. PubMed PMID: 21822255.
- Toung JM, Morley M, Li M, Cheung VG. RNA-sequence analysis of human B-cells. Genome Res. 2011 Jun;21(6):991-8. Epub 2011 May 2. PubMed PMID: 21536721; PubMed Central PMCID: PMC3106332.
- An attempt to find out an appropriate coverage of gene expression by next-generation sequencing.
- See more discussions in this blog.
Retina
- Nelson BR, Ueki Y, Reardon S, Karl MO, Georgi S, Hartman BH, Lamba DA, Reh TA. Genome-wide analysis of müller glial differentiation reveals a requirement for notch signaling in postmitotic cells to maintain the glial fate. PLoS One. 2011;6(8):e22817. Epub 2011 Aug 2. PubMed PMID: 21829655; PubMed Central PMCID: PMC3149061.
- Esteve P, Sandonìs A, Ibañez C, Shimono A, Guerrero I, Bovolenta P. Secreted frizzled-related proteins are required for Wnt/{beta}-catenin signalling activation in the vertebrate optic cup. Development. 2011 Oct;138(19):4179-84. PubMed PMID: 21896628.
Eye Disease
- Kinori M, Pras E, Kolker A, Ferman-Attar G, Moroz I, Moisseiev J, Bandah-Rozenfeld D, Mizrahi-Meissonnier L, Sharon D, Rotenstreich Y. Enhanced S-cone function with preserved rod function: a new clinical phenotype. Mol Vis. 2011;17:2241-7. Epub 2011 Aug 18. PubMed PMID: 21897746.
Education
- Amsen E. Leaving the lab: career development for developmental biologists. Development. 2011 Oct;138(19):4107-9. PubMed PMID: 21896625.
Molecular Biology
- Proudfoot NJ. Ending the message: poly(A) signals then and now. Genes Dev. 2011 Sep 1;25(17):1770-82. PubMed PMID: 21896654.
Systems Biology
- Huh D, Paulsson J. Random partitioning of molecules at cell division. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):15004-9. Epub 2011 Aug 22. PubMed PMID: 21873252.
Gene therapy
- Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011 Aug 25;365(8):725-33. Epub 2011 Aug 10. PubMed PMID: 21830940.
- Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med. 2011 Aug 10;3(95):95ra73. PubMed PMID: 21832238.
- Two interesting articles about using attenuated HIV as the vector for gene therapy for leukemia
- News coverage: An Immune System Trained to Kill Cancer