Leung Lab Blog

Retina & regeneration

1. Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T. CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors. Genome Res. 2010 Nov;20(11):1512-25. Epub 2010 Aug 6. PubMed PMID: 20693478.
2. Ramachandran R, Fausett BV, Goldman D. Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol. 2010 Nov;12(11):1101-7. Epub 2010 Oct 10. PubMed PMID: 20935637; PubMed Central PMCID: PMC2972404.
3. Choy SW, Cheng CW, Lee ST, Li VW, Hui MN, Hui CC, Liu D, Cheng SH.  A cascade of irx1a and irx2a controls shh expression during retinogenesis. Dev Dyn. 2010 Nov 2;. [Epub ahead of print]
4. Choi JH, Law MY, Chien CB, Link BA, Wong RO. In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. Neural Dev. 2010 Nov 2;5(1):29. [Epub ahead of print] PubMed PMID: 21044295.

Development

1. Apodaca G. Opening ahead: early steps in lumen formation revealed. Nat Cell Biol. 2010 Nov;12(11):1026-8. PubMed PMID: 21045801.
2. Morris JA, Royall JJ, Bertagnolli D, Boe AF, Burnell JJ, Byrnes EJ, Copeland C, Desta T, Fischer SR, Goldy J, Glattfelder KJ, Kidney JM, Lemon T, Orta GJ, Parry SE, Pathak SD, Pearson OC, Reding M, Shapouri S, Smith KA, Soden C, Solan BM, Weller J, Takahashi JS, Overly CC, Lein ES, Hawrylycz MJ, Hohmann JG, Jones AR. Divergent and nonuniform gene expression patterns in mouse brain. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19049-54. Epub 2010 Oct 18. PubMed PMID: 20956311.
3. Pedersen MT, Helin K. Histone demethylases in development and disease. Trends  Cell Biol. 2010 Nov;20(11):662-71. Epub 2010 Sep 20. PubMed PMID: 20863703.

Gene regulatory network & Systems biology

1. Cotterell J, Sharpe J. An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients. Mol Syst Biol. 2010 Nov 2;6:425. PubMed PMID: 21045819.
2. Salazar C, Brümmer A, Alberghina L, Höfer T. Timing control in regulatory networks by multisite protein modifications. Trends Cell Biol. 2010 Nov;20(11):634-41. Epub 2010 Sep 23. PubMed PMID: 20869247.

Disease

1. Van Broeckhoven C. The future of genetic research on neurodegeneration. Nat Med. 2010 Nov;16(11):1215-7. Epub 2010 Sep 21. PubMed PMID: 21052076.
2. Jucker M. The benefits and limitations of animal models for translational research in neurodegenerative diseases. Nat Med. 2010 Nov;16(11):1210-4. Epub 2010 Sep 21. PubMed PMID: 21052075.
3. Haass C. Initiation and propagation of neurodegeneration. Nat Med. 2010 Nov;16(11):1201-4. Epub 2010 Sep 21. PubMed PMID: 21052073.
4. Jacobson SG, Cideciyan AV. Treatment possibilities for retinitis pigmentosa. N Engl J Med. 2010 Oct 21;363(17):1669-71. PubMed PMID: 20961252.