Leung Lab Blog

Genomics

1. Rothberg JM, Hinz W, Rearick TM, Schultz J, Mileski W, Davey M, Leamon JH, Johnson K, Milgrew MJ, Edwards M, Hoon J, Simons JF, Marran D, Myers JW, Davidson JF, Branting A, Nobile JR, Puc BP, Light D, Clark TA, Huber M, Branciforte JT,Stoner IB, Cawley SE, Lyons M, Fu Y, Homer N, Sedova M, Miao X, Reed B, Sabina J, Feierstein E, Schorn M, Alanjary M, Dimalanta E, Dressman D, Kasinskas R, Sokolsky T, Fidanza JA, Namsaraev E, McKernan KJ, Williams A, Roth GT, Bustillo J. An integrated semiconductor device enabling non-optical genome sequencing. Nature. 2011 Jul 20;475(7356):348-52. doi: 10.1038/nature10242. PubMed PMID: 21776081.
• A new and promising way of sequencing.
2. Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat Methods. 2011 Jul 17;8(9):753-5. doi: 10.1038/nmeth.1653. PubMed PMID: 21765410.

Imaging

1. Truong TV, Supatto W, Koos DS, Choi JM, Fraser SE. Deep and fast live imaging  with two-photon scanned light-sheet microscopy. Nat Methods. 2011 Jul 17;8(9):757-60. doi: 10.1038/nmeth.1652. PubMed PMID: 21765409.

Medicine

1. Rosenbaum L. The art of doing nothing. N Engl J Med. 2011 Sep;365(9):782-5. PubMed PMID: 21879895.

Systems Biology

1. Srivas R, Hannum G, Ruscheinski J, Ono K, Wang PL, Smoot M, Ideker T. Assembling global maps of cellular function through integrative analysis of physical and genetic networks. Nat Protoc. 2011 Aug 11;6(9):1308-23. doi: 10.1038/nprot.2011.368. PubMed PMID: 21886098.
2. Modi SR, Camacho DM, Kohanski MA, Walker GC, Collins JJ. Functional characterization of bacterial sRNAs using a network biology approach. Proc Natl Acad Sci U S A. 2011 Aug 29. [Epub ahead of print] PubMed PMID: 21876160.
3. Murrugarra D, Laubenbacher R. Regulatory patterns in molecular interaction networks. J Theor Biol. 2011 Aug 25. [Epub ahead of print] PubMed PMID: 21872607.

Evolution

1. Flajnik MF, Deschacht N, Muyldermans S. A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels? PLoS Biol. 2011 Aug;9(8):e1001120. Epub 2011 Aug 2. PubMed PMID: 21829328; PubMed Central PMCID: PMC3149040.
2. Reed RD, Papa R, Martin A, Hines HM, Counterman BA, Pardo-Diaz C, Jiggins CD, Chamberlain NL, Kronforst MR, Chen R, Halder G, Nijhout HF, McMillan WO. optix drives the repeated convergent evolution of butterfly wing pattern mimicry. Science. 2011 Aug 26;333(6046):1137-41. Epub 2011 Jul 21. PubMed PMID: 21778360.
• Commentary: Carroll SB. Evolution. How great wings can look alike. Science. 2011 Aug 26;333(6046):1100-1. PubMed PMID: 21868661.

Cancer

1. Brakenhoff RH. Cancer. Another NOTCH for cancer. Science. 2011 Aug 26;333(6046):1102-3. PubMed PMID: 21868662.
2. Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Schöll C, Tothova Z, Attar EC, Fröhling S, Depinho RA, Armstrong SA, Gilliland DG, Scadden DT. AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias. Cell. 2011 Sep 2;146(5):697-708. PubMed PMID: 21884932.
• Commentary: Downing JR. A New FOXO Pathway Required for Leukemogenesis. Cell. 2011 Sep 2;146(5):669-70. PubMed PMID: 21884926.

Regeneration

1. Smith J, Morgan JR, Zottoli SJ, Smith PJ, Buxbaum JD, Bloom OE. Regeneration in the era of functional genomics and gene network analysis. Biol Bull. 2011 Aug;221(1):18-34. PubMed PMID: 21876108.

Plant

1. Jorgensen RA. Plant science. A window on the sophistication of plants. Science. 2011 Aug 26;333(6046):1103-4. PubMed PMID: 21868663.

Philosophy

1. Vilela M, Danuser G. What’s wrong with correlative experiments? Nat Cell Biol. 2011 Sep 2;13(9):1011. doi: 10.1038/ncb2325. PubMed PMID: 21892139.