{"id":154,"date":"2009-06-30T00:09:06","date_gmt":"2009-06-30T05:09:06","guid":{"rendered":"https:\/\/leung.bio.purdue.edu\/blog\/?p=154"},"modified":"2009-07-16T07:38:14","modified_gmt":"2009-07-16T12:38:14","slug":"the-scientists-behind-the-meselson-stahl-experiment","status":"publish","type":"post","link":"https:\/\/leung.bio.purdue.edu\/blog\/the-scientists-behind-the-meselson-stahl-experiment\/","title":{"rendered":"The scientists behind the Meselson-Stahl experiment"},"content":{"rendered":"<p>The other day we talked about the historical moment when Matt Meselson and Frank Stahl elucidated the semi-conservative mechanism of DNA replication.<\/p>\n<p><a href=\"http:\/\/www.pnas.org\/content\/101\/52\/17889.full.pdf+html\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" title=\"Matt Meselson and Frank Stahl at Woods hole\" src=\"http:\/\/www.pnas.org\/content\/101\/52\/17889\/F1.medium.gif\" alt=\"\" width=\"292\" height=\"440\" \/><\/a><\/p>\n<p>We briefly discussed the challenges that they faced at that time as a graduate student and a postdoc, which I think would give us insights to face our own challenges. I am still reading the <a href=\"http:\/\/www.amazon.com\/Meselson-Stahl-Replication-DNA-Experiment\/dp\/0300085400\/ref=sr_1_1?ie=UTF8&amp;s=books&amp;qid=1246338262&amp;sr=8-1\">longer book<\/a> about the history behind this experiment. I think it is a very entertaining read but it is also very thick. A shorter historical account published in the PNAS would be easier for many of us to get an overall impression of the story.<\/p>\n<p><em>References:<\/em><\/p>\n<p>Hanawalt PC. Density matters: the semiconservative replication of DNA. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17889-94. [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15608066\">PubMed<\/a>][<a href=\"http:\/\/www.pnas.org\/content\/101\/52\/17889.full.pdf+html\">pdf<\/a>]<br \/>\nHolmes FL. Meselson, Stahl, and the Replication of DNA: A History of &#8216;The Most Beautiful Experiment in Biology&#8217; [<a href=\"http:\/\/www.amazon.com\/Meselson-Stahl-Replication-DNA-Experiment\/dp\/0300085400\/ref=sr_1_1?ie=UTF8&amp;s=books&amp;qid=1246338262&amp;sr=8-1\">Amazon<\/a>]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The other day we talked about the historical moment when Matt Meselson and Frank Stahl elucidated the semi-conservative mechanism of DNA replication. We briefly discussed the challenges that they faced at that time as a graduate student and a postdoc, which I think would give us insights to face our own challenges. I am still [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,43],"tags":[45,47,450,44,46,49,48],"class_list":["post-154","post","type-post","status-publish","format-standard","hentry","category-faisharing","category-history-of-science","tag-dna","tag-frank-stahl","tag-history-of-science","tag-marine-biological-laboratory","tag-matt-meselson","tag-replication","tag-semi-conservative"],"_links":{"self":[{"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/posts\/154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/comments?post=154"}],"version-history":[{"count":5,"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/posts\/154\/revisions"}],"predecessor-version":[{"id":183,"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/posts\/154\/revisions\/183"}],"wp:attachment":[{"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/media?parent=154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/categories?post=154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/leung.bio.purdue.edu\/blog\/wp-json\/wp\/v2\/tags?post=154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}